Cargando…

The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model

The dense tumor stroma of pancreatic ductal adenocarcinoma (PDAC) and its secreted immune active molecules provide a barrier for chemotherapy treatment as well as for immune cell infiltration to the tumor core, providing a challenge for immunotherapeutic strategies. Consequently, the investigation o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geyer, Marlene, Gaul, Lisa-Marie, D`Agosto, Sabrina Luigia, Corbo, Vincenzo, Queiroz, Karla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185841/ https://www.ncbi.nlm.nih.gov/pubmed/37205118 http://dx.doi.org/10.3389/fimmu.2023.1155085

Ejemplares similares

A microfluidic-based PDAC organoid system reveals the impact of hypoxia in response to treatment
por: Geyer, Marlene, et al.
Publicado: (2023)

Combinatorial Effect of Magnetic Field and Radiotherapy in PDAC Organoids: A Pilot Study
por: Nicosia, Luca, et al.
Publicado: (2020)

Cell Lineage Infidelity in PDAC Progression and Therapy Resistance
por: Malinova, Antonia, et al.
Publicado: (2021)

Cohort Analysis of ADAM8 Expression in the PDAC Tumor Stroma
por: Jaworek, Christian, et al.
Publicado: (2021)

Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC
por: Strell, Carina, et al.
Publicado: (2017)

Loss of FGFR4 promotes the malignant phenotype of PDAC
por: D’Agosto, Sabrina, et al.
Publicado: (2022)

Whole-body bioluminescence imaging of T-cell response in PDAC models
por: McMorrow, Roisin, et al.
Publicado: (2023)

Tumor-Stroma Interaction in PDAC as a New Approach for Liquid Biopsy and its Potential Clinical Implications
por: Götze, Julian, et al.
Publicado: (2022)

In Silico analyses of host immunity and stroma provide prognostic factors in early stage pancreatic ductal adenocarcinoma (PDAC)
por: Williams, Madison H., et al.
Publicado: (2020)

Generation of Pancreatic Organoid-Derived Isografts
por: D’Agosto, Sabrina, et al.
Publicado: (2020)

Microfluidic Platforms for High-Throughput Pancreatic Ductal Adenocarcinoma Organoid Culture and Drug Screening
por: Geyer, Marlene, et al.
Publicado: (2021)

Role of Serine Proteases at the Tumor-Stroma Interface
por: Tagirasa, Ravichandra, et al.
Publicado: (2022)

Stroma cell priming in enteric lymphoid organ morphogenesis
por: Ferreira, Manuela, et al.
Publicado: (2012)

Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma
por: Martinez-Zubiaurre, Inigo, et al.
Publicado: (2018)

Role of Radiation Therapy in Modulation of the Tumor Stroma and Microenvironment
por: Menon, Hari, et al.
Publicado: (2019)

Immune features of the peritumoral stroma in pancreatic ductal adenocarcinoma
por: Ahmed, Azaz, et al.
Publicado: (2022)

Preclinical Modelling of PDA: Is Organoid the New Black?
por: D’Agosto, Sabrina, et al.
Publicado: (2019)

Rag Defects and Thymic Stroma: Lessons from Animal Models
por: Marrella, Veronica, et al.
Publicado: (2014)

Coordination of Immune-Stroma Crosstalk by IL-6 Family Cytokines
por: West, Nathaniel R.
Publicado: (2019)

The Roles of Stroma-Derived Chemokine in Different Stages of Cancer Metastases
por: Hussain, Shahid, et al.
Publicado: (2020)

Virotherapy combined with anti-PD-1 transiently reshapes the tumor immune environment and induces anti-tumor immunity in a preclinical PDAC model
por: Veinalde, Rūta, et al.
Publicado: (2023)

Scaling the immune incline in PDAC
por: Rojas, Luis A., et al.
Publicado: (2021)

Hedgehog Signaling in Colorectal Cancer: All in the Stroma?
por: Geyer, Natalie, et al.
Publicado: (2021)

Development of Two Distinct Dendritic-Like APCs in the Context of Splenic Stroma
por: Periasamy, Pravin, et al.
Publicado: (2013)

Corrigendum: Rag Defects and Thymic Stroma: Lessons from Animal Models
por: Marrella, Veronica, et al.
Publicado: (2014)

Functional and Homeostatic Impact of Age-Related Changes in Lymph Node Stroma
por: Thompson, Heather L., et al.
Publicado: (2017)

Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells–Peritoneal Stroma Interactions
por: Terri, Michela, et al.
Publicado: (2021)

TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion
por: You, Yuan, et al.
Publicado: (2021)

Transverse Space Charge Effect During Bunch Compression in PDAC1 and PDAC2 Compressor Ring
por: Franchetti, Giuliano
Publicado: (2000)

The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC
por: Brown, Matthew, et al.
Publicado: (2020)

Breast cancer stroma frequently recruits fetal derived cells during pregnancy
por: Dubernard, Gil, et al.
Publicado: (2008)

Assessment of stromal SCD-induced drug resistance of PDAC using 3D-printed zPDX model chips
por: Wu, Chuntao, et al.
Publicado: (2022)

Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins
por: Liot, Sophie, et al.
Publicado: (2021)

Autophagy is required for PDAC glutamine metabolism
por: Seo, Ju-Won, et al.
Publicado: (2016)

SIRT 1 Overexpression is Associated with Metastasis of Pancreatic Ductal Adenocarcinoma (PDAC) and Promotes Migration and Growth of PDAC Cells
por: Li, Siqin, et al.
Publicado: (2016)

Collagen Organization Does Not Influence T-Cell Distribution in Stroma of Human Pancreatic Cancer
por: Kamionka, Eva-Maria, et al.
Publicado: (2021)

Thymic B Cell-Mediated Attack of Thymic Stroma Precedes Type 1 Diabetes Development
por: Pinto, Ana Isabel, et al.
Publicado: (2018)

Premature thymic involution is independent of structural plasticity of the thymic stroma
por: Franckaert, Dean, et al.
Publicado: (2015)

Overexpression of Mesothelin in Pancreatic Ductal Adenocarcinoma (PDAC)
por: Le, Kai, et al.
Publicado: (2020)

The Microbiome in PDAC—Vantage Point for Future Therapies?
por: Pfisterer, Nina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_umgbuomon948v039fftjsmk0cf