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CD25 targeting with the afucosylated human IgG1 antibody RG6292 eliminates regulatory T cells and CD25+ blasts in acute myeloid leukemia

BACKGROUND: Acute Myeloid leukemia is a heterogeneous disease that requires novel targeted treatment options tailored to the patients’ specific microenvironment and blast phenotype. METHODS: We characterized bone marrow and/or blood samples of 37 AML patients and healthy donors by high dimensional f...

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Detalles Bibliográficos
Autores principales:	Pousse, Laurène, Korfi, Koorosh, Medeiros, Bruno C., Berrera, Marco, Kumpesa, Nadine, Eckmann, Jan, Hutter, Idil Karakoc, Griesser, Vera, Karanikas, Vaios, Klein, Christian, Amann, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185852/ https://www.ncbi.nlm.nih.gov/pubmed/37205201 http://dx.doi.org/10.3389/fonc.2023.1150149

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