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The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a global health crisis. Increasing evidence underlines the key role of competent immune responses in resisting SARS-CoV-2 infection and manifests the disastrous consequen...

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Autores principales: Wang, Man, Zhang, Yuan, Li, Chunmei, Chang, Wenguang, Zhang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185909/
https://www.ncbi.nlm.nih.gov/pubmed/37205106
http://dx.doi.org/10.3389/fimmu.2023.1180336
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author Wang, Man
Zhang, Yuan
Li, Chunmei
Chang, Wenguang
Zhang, Lei
author_facet Wang, Man
Zhang, Yuan
Li, Chunmei
Chang, Wenguang
Zhang, Lei
author_sort Wang, Man
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a global health crisis. Increasing evidence underlines the key role of competent immune responses in resisting SARS-CoV-2 infection and manifests the disastrous consequence of host immune dysregulation. Elucidating the mechanisms responsible for deregulated host immunity in COVID-19 may provide a theoretical basis for further research on new treatment modalities. Gut microbiota comprises trillions of microorganisms colonizing the human gastrointestinal tract and has a vital role in immune homeostasis and the gut-lung crosstalk. Particularly, SARS-CoV-2 infection can lead to the disruption of gut microbiota equilibrium, a condition called gut dysbiosis. Due to its regulatory effect on host immunity, gut microbiota has recently received considerable attention in the field of SARS-CoV-2 immunopathology. Imbalanced gut microbiota can fuel COVID-19 progression through production of bioactive metabolites, intestinal metabolism, enhancement of the cytokine storm, exaggeration of inflammation, regulation of adaptive immunity and other aspects. In this review, we provide an overview of the alterations in gut microbiota in COVID-19 patients, and their effects on individuals’ susceptibility to viral infection and COVID-19 progression. Moreover, we summarize currently available data on the critical role of the bidirectional regulation between intestinal microbes and host immunity in SARS-CoV-2-induced pathology, and highlight the immunomodulatory mechanisms of gut microbiota contributing to COVID-19 pathogenesis. In addition, we discuss the therapeutic benefits and future perspectives of microbiota-targeted interventions including faecal microbiota transplantation (FMT), bacteriotherapy and traditional Chinese medicine (TCM) in COVID-19 treatment.
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spelling pubmed-101859092023-05-17 The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment Wang, Man Zhang, Yuan Li, Chunmei Chang, Wenguang Zhang, Lei Front Immunol Immunology The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a global health crisis. Increasing evidence underlines the key role of competent immune responses in resisting SARS-CoV-2 infection and manifests the disastrous consequence of host immune dysregulation. Elucidating the mechanisms responsible for deregulated host immunity in COVID-19 may provide a theoretical basis for further research on new treatment modalities. Gut microbiota comprises trillions of microorganisms colonizing the human gastrointestinal tract and has a vital role in immune homeostasis and the gut-lung crosstalk. Particularly, SARS-CoV-2 infection can lead to the disruption of gut microbiota equilibrium, a condition called gut dysbiosis. Due to its regulatory effect on host immunity, gut microbiota has recently received considerable attention in the field of SARS-CoV-2 immunopathology. Imbalanced gut microbiota can fuel COVID-19 progression through production of bioactive metabolites, intestinal metabolism, enhancement of the cytokine storm, exaggeration of inflammation, regulation of adaptive immunity and other aspects. In this review, we provide an overview of the alterations in gut microbiota in COVID-19 patients, and their effects on individuals’ susceptibility to viral infection and COVID-19 progression. Moreover, we summarize currently available data on the critical role of the bidirectional regulation between intestinal microbes and host immunity in SARS-CoV-2-induced pathology, and highlight the immunomodulatory mechanisms of gut microbiota contributing to COVID-19 pathogenesis. In addition, we discuss the therapeutic benefits and future perspectives of microbiota-targeted interventions including faecal microbiota transplantation (FMT), bacteriotherapy and traditional Chinese medicine (TCM) in COVID-19 treatment. Frontiers Media S.A. 2023-05-02 /pmc/articles/PMC10185909/ /pubmed/37205106 http://dx.doi.org/10.3389/fimmu.2023.1180336 Text en Copyright © 2023 Wang, Zhang, Li, Chang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Man
Zhang, Yuan
Li, Chunmei
Chang, Wenguang
Zhang, Lei
The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment
title The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment
title_full The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment
title_fullStr The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment
title_full_unstemmed The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment
title_short The relationship between gut microbiota and COVID-19 progression: new insights into immunopathogenesis and treatment
title_sort relationship between gut microbiota and covid-19 progression: new insights into immunopathogenesis and treatment
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185909/
https://www.ncbi.nlm.nih.gov/pubmed/37205106
http://dx.doi.org/10.3389/fimmu.2023.1180336
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