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Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting
OBJECTIVE: Identifying clinical and laboratory indicators that differentiate multisystem inflammatory syndrome in children (MIS-C) apart from other febrile diseases in a tropical hospital setting. METHODS: Review of hospital records done in a tertiary care exclusive children’s hospital for children...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185926/ https://www.ncbi.nlm.nih.gov/pubmed/36896750 http://dx.doi.org/10.1007/s13312-023-2884-3 |
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author | Balasubramanian, S. Sankar, Janani Dhanalakshmi, K. Lakshan Raj, S. Nandakumar, Divya Ramanan, A. V. Chandy, Sara |
author_facet | Balasubramanian, S. Sankar, Janani Dhanalakshmi, K. Lakshan Raj, S. Nandakumar, Divya Ramanan, A. V. Chandy, Sara |
author_sort | Balasubramanian, S. |
collection | PubMed |
description | OBJECTIVE: Identifying clinical and laboratory indicators that differentiate multisystem inflammatory syndrome in children (MIS-C) apart from other febrile diseases in a tropical hospital setting. METHODS: Review of hospital records done in a tertiary care exclusive children’s hospital for children admitted from April, 2020 till June, 2021. Laboratory values, severe acute respiratory syndrome coronavirus (SARS-CoV-2) serological status, and clinical signs and symptoms of patients with MIS-C, and those with similar presentations were analyzed. RESULTS: 114 children fulfilled the inclusion criteria (age group of 1 mo-18 y) for whom a diagnosis of MIS-C was considered in the emergency room based on the clinical features. Among them, 64 children had the final diagnosis of MIS-C, and the remaining 50 children had confirmatory evidence of infections mimicking MIS-C such as enteric fever, scrub typhus, dengue and appendicitis. CONCLUSION: Older age group, presence of mucocutaneous symptoms, very high C-reactive protein, neutrophilic leukocytosis, abdominal pain and absence of hepatosplenomegaly favor a diagnosis of MIS-C. |
format | Online Article Text |
id | pubmed-10185926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-101859262023-05-17 Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting Balasubramanian, S. Sankar, Janani Dhanalakshmi, K. Lakshan Raj, S. Nandakumar, Divya Ramanan, A. V. Chandy, Sara Indian Pediatr Research Paper OBJECTIVE: Identifying clinical and laboratory indicators that differentiate multisystem inflammatory syndrome in children (MIS-C) apart from other febrile diseases in a tropical hospital setting. METHODS: Review of hospital records done in a tertiary care exclusive children’s hospital for children admitted from April, 2020 till June, 2021. Laboratory values, severe acute respiratory syndrome coronavirus (SARS-CoV-2) serological status, and clinical signs and symptoms of patients with MIS-C, and those with similar presentations were analyzed. RESULTS: 114 children fulfilled the inclusion criteria (age group of 1 mo-18 y) for whom a diagnosis of MIS-C was considered in the emergency room based on the clinical features. Among them, 64 children had the final diagnosis of MIS-C, and the remaining 50 children had confirmatory evidence of infections mimicking MIS-C such as enteric fever, scrub typhus, dengue and appendicitis. CONCLUSION: Older age group, presence of mucocutaneous symptoms, very high C-reactive protein, neutrophilic leukocytosis, abdominal pain and absence of hepatosplenomegaly favor a diagnosis of MIS-C. Springer India 2023-03-10 2023 /pmc/articles/PMC10185926/ /pubmed/36896750 http://dx.doi.org/10.1007/s13312-023-2884-3 Text en © Indian Academy of Pediatrics 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Research Paper Balasubramanian, S. Sankar, Janani Dhanalakshmi, K. Lakshan Raj, S. Nandakumar, Divya Ramanan, A. V. Chandy, Sara Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting |
title | Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting |
title_full | Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting |
title_fullStr | Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting |
title_full_unstemmed | Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting |
title_short | Differentiating Multisystem Inflammatory Syndrome in Children (MIS-C) and Its Mimics–A Single-Center Experience From a Tropical Setting |
title_sort | differentiating multisystem inflammatory syndrome in children (mis-c) and its mimics–a single-center experience from a tropical setting |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185926/ https://www.ncbi.nlm.nih.gov/pubmed/36896750 http://dx.doi.org/10.1007/s13312-023-2884-3 |
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