Cargando…
The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency
BACKGROUND: This study aimed to investigate the relationship between maternal predisposing factors with the level of maternal serum pregnancy-associated plasma protein A and free subunit human chorionic gonadotropin and nuchal translucency. MATERIALS AND METHODS: We performed a cross-sectional-analy...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186050/ https://www.ncbi.nlm.nih.gov/pubmed/37200754 http://dx.doi.org/10.4103/abr.abr_54_21 |
_version_ | 1785042489724370944 |
---|---|
author | Mirsafaie, Maryam Kheirollahi, Majid Moghaddam-Banaem, Lida |
author_facet | Mirsafaie, Maryam Kheirollahi, Majid Moghaddam-Banaem, Lida |
author_sort | Mirsafaie, Maryam |
collection | PubMed |
description | BACKGROUND: This study aimed to investigate the relationship between maternal predisposing factors with the level of maternal serum pregnancy-associated plasma protein A and free subunit human chorionic gonadotropin and nuchal translucency. MATERIALS AND METHODS: We performed a cross-sectional-analytical study on 762 pregnant women who referred to the Gene Azma Medical Genetics Laboratory in Isfahan for amniocentesis. All pregnant women at high risk of screening in the first trimester of pregnancy for trisomy 21 and other aneuploidy were referred to a gynecologist for amniotic fluid sampling (amniocentesis). Multiple of the means (MoM) of PAPPA ≤0.5, 0.5 ≥ MoM free β-hCG >2.5, and NT ≥3.5 mm were considered abnormal. We used Chi-square method and Mann–Whitney U-test to compare data qualitative and quantitative, respectively. RESULTS: In individuals with less pregnancies and deliveries, the value of abnormal NT was higher (P < 0.01, P < 0.001, respectively). On the other hand, the highest abnormal rate of NT was observed in pregnant women under 35 years (21, 84%, P < 0.012). In addition, abnormal levels of free β-hCG are more common in women < 35 years of age (186, 66.9%, P < 0.02) and female fetuses (171, 58.8%) (P < 0.006). CONCLUSION: According to the results of this study, it can be said that considering the underlying factors of pregnant mothers in performing tests related to screening in the first trimester of pregnancy can lead to a reduction in false positive rates. |
format | Online Article Text |
id | pubmed-10186050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-101860502023-05-17 The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency Mirsafaie, Maryam Kheirollahi, Majid Moghaddam-Banaem, Lida Adv Biomed Res Original Article BACKGROUND: This study aimed to investigate the relationship between maternal predisposing factors with the level of maternal serum pregnancy-associated plasma protein A and free subunit human chorionic gonadotropin and nuchal translucency. MATERIALS AND METHODS: We performed a cross-sectional-analytical study on 762 pregnant women who referred to the Gene Azma Medical Genetics Laboratory in Isfahan for amniocentesis. All pregnant women at high risk of screening in the first trimester of pregnancy for trisomy 21 and other aneuploidy were referred to a gynecologist for amniotic fluid sampling (amniocentesis). Multiple of the means (MoM) of PAPPA ≤0.5, 0.5 ≥ MoM free β-hCG >2.5, and NT ≥3.5 mm were considered abnormal. We used Chi-square method and Mann–Whitney U-test to compare data qualitative and quantitative, respectively. RESULTS: In individuals with less pregnancies and deliveries, the value of abnormal NT was higher (P < 0.01, P < 0.001, respectively). On the other hand, the highest abnormal rate of NT was observed in pregnant women under 35 years (21, 84%, P < 0.012). In addition, abnormal levels of free β-hCG are more common in women < 35 years of age (186, 66.9%, P < 0.02) and female fetuses (171, 58.8%) (P < 0.006). CONCLUSION: According to the results of this study, it can be said that considering the underlying factors of pregnant mothers in performing tests related to screening in the first trimester of pregnancy can lead to a reduction in false positive rates. Wolters Kluwer - Medknow 2023-03-21 /pmc/articles/PMC10186050/ /pubmed/37200754 http://dx.doi.org/10.4103/abr.abr_54_21 Text en Copyright: © 2023 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Mirsafaie, Maryam Kheirollahi, Majid Moghaddam-Banaem, Lida The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency |
title | The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency |
title_full | The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency |
title_fullStr | The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency |
title_full_unstemmed | The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency |
title_short | The Impact of Maternal Predisposing Factors on Level of Maternal Serum Pregnancy-Associated Plasma Protein A and Free Subunit Human Chorionic Gonadotropin and Nuchal Translucency |
title_sort | impact of maternal predisposing factors on level of maternal serum pregnancy-associated plasma protein a and free subunit human chorionic gonadotropin and nuchal translucency |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186050/ https://www.ncbi.nlm.nih.gov/pubmed/37200754 http://dx.doi.org/10.4103/abr.abr_54_21 |
work_keys_str_mv | AT mirsafaiemaryam theimpactofmaternalpredisposingfactorsonlevelofmaternalserumpregnancyassociatedplasmaproteinaandfreesubunithumanchorionicgonadotropinandnuchaltranslucency AT kheirollahimajid theimpactofmaternalpredisposingfactorsonlevelofmaternalserumpregnancyassociatedplasmaproteinaandfreesubunithumanchorionicgonadotropinandnuchaltranslucency AT moghaddambanaemlida theimpactofmaternalpredisposingfactorsonlevelofmaternalserumpregnancyassociatedplasmaproteinaandfreesubunithumanchorionicgonadotropinandnuchaltranslucency AT mirsafaiemaryam impactofmaternalpredisposingfactorsonlevelofmaternalserumpregnancyassociatedplasmaproteinaandfreesubunithumanchorionicgonadotropinandnuchaltranslucency AT kheirollahimajid impactofmaternalpredisposingfactorsonlevelofmaternalserumpregnancyassociatedplasmaproteinaandfreesubunithumanchorionicgonadotropinandnuchaltranslucency AT moghaddambanaemlida impactofmaternalpredisposingfactorsonlevelofmaternalserumpregnancyassociatedplasmaproteinaandfreesubunithumanchorionicgonadotropinandnuchaltranslucency |