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Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats
BACKGROUND: Considering antioxidant effects of vitamin E (Vit E), in the present study, the effect of Vit E on liver and kidney functions and oxidative stress parameters in tissues of these organs of hypothyroid (Hypo) rats were reported. MATERIALS AND METHODS: The animals were included in three gro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186051/ https://www.ncbi.nlm.nih.gov/pubmed/37200753 http://dx.doi.org/10.4103/abr.abr_275_21 |
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author | Hedayati-Moghadam, Mahdiyeh Baghcheghi, Yousef Beheshti, Farimah Shabgah, Arezoo G. Salmani, Hossein Hosseini, Mahmoud |
author_facet | Hedayati-Moghadam, Mahdiyeh Baghcheghi, Yousef Beheshti, Farimah Shabgah, Arezoo G. Salmani, Hossein Hosseini, Mahmoud |
author_sort | Hedayati-Moghadam, Mahdiyeh |
collection | PubMed |
description | BACKGROUND: Considering antioxidant effects of vitamin E (Vit E), in the present study, the effect of Vit E on liver and kidney functions and oxidative stress parameters in tissues of these organs of hypothyroid (Hypo) rats were reported. MATERIALS AND METHODS: The animals were included in three groups:(1) control, (2) hypo, and (3) hypo-hypo-Vit E. Hypothyroidism was induced in rats by giving 0.05% propylthiouracil (PTU) in drinking water. Besides PTU, the rats in group 3 were daily injected with Vit E (20 mg/kg) for 42 days. The animals were deeply anesthetized and sacrificed, and the serum of the rats was immediately removed to measure thyroxin level and subsequent analysis. The liver and kidney tissues were also immediately removed for biochemical oxidative stress criteria. RESULTS: PTU administration reduced serum thyroxin level and also thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the liver and kidney tissues while increasing malondialdehyde (MDA). Hypothyroidism also increased alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine while decreasing albumin. Vit E increased thiol, SOD, and CAT in the liver and kidney tissues while diminished MDA. Vit E also decreased ALT, BUN, and creatinine while increased albumin. CONCLUSION: The results of this study showed that Vit E prevented liver and renal tissue damage in hypothyroid rats. |
format | Online Article Text |
id | pubmed-10186051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-101860512023-05-17 Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats Hedayati-Moghadam, Mahdiyeh Baghcheghi, Yousef Beheshti, Farimah Shabgah, Arezoo G. Salmani, Hossein Hosseini, Mahmoud Adv Biomed Res Original Article BACKGROUND: Considering antioxidant effects of vitamin E (Vit E), in the present study, the effect of Vit E on liver and kidney functions and oxidative stress parameters in tissues of these organs of hypothyroid (Hypo) rats were reported. MATERIALS AND METHODS: The animals were included in three groups:(1) control, (2) hypo, and (3) hypo-hypo-Vit E. Hypothyroidism was induced in rats by giving 0.05% propylthiouracil (PTU) in drinking water. Besides PTU, the rats in group 3 were daily injected with Vit E (20 mg/kg) for 42 days. The animals were deeply anesthetized and sacrificed, and the serum of the rats was immediately removed to measure thyroxin level and subsequent analysis. The liver and kidney tissues were also immediately removed for biochemical oxidative stress criteria. RESULTS: PTU administration reduced serum thyroxin level and also thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the liver and kidney tissues while increasing malondialdehyde (MDA). Hypothyroidism also increased alanine aminotransferase (ALT), blood urea nitrogen (BUN), and creatinine while decreasing albumin. Vit E increased thiol, SOD, and CAT in the liver and kidney tissues while diminished MDA. Vit E also decreased ALT, BUN, and creatinine while increased albumin. CONCLUSION: The results of this study showed that Vit E prevented liver and renal tissue damage in hypothyroid rats. Wolters Kluwer - Medknow 2023-03-28 /pmc/articles/PMC10186051/ /pubmed/37200753 http://dx.doi.org/10.4103/abr.abr_275_21 Text en Copyright: © 2023 Advanced Biomedical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Hedayati-Moghadam, Mahdiyeh Baghcheghi, Yousef Beheshti, Farimah Shabgah, Arezoo G. Salmani, Hossein Hosseini, Mahmoud Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats |
title | Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats |
title_full | Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats |
title_fullStr | Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats |
title_full_unstemmed | Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats |
title_short | Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats |
title_sort | vitamin e prevented hepatic and renal tissue damage in hypothyroid rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186051/ https://www.ncbi.nlm.nih.gov/pubmed/37200753 http://dx.doi.org/10.4103/abr.abr_275_21 |
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