Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice

Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn strongly correl...

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Autores principales: Liu, Li, Liu, Biting, Wang, Lian, Li, Caixia, Zhou, Yang, Zhu, Jihui, Ding, Jinye, Liu, Shupeng, Cheng, Zhongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186293/
https://www.ncbi.nlm.nih.gov/pubmed/37194006
http://dx.doi.org/10.1186/s12958-023-01097-3
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author Liu, Li
Liu, Biting
Wang, Lian
Li, Caixia
Zhou, Yang
Zhu, Jihui
Ding, Jinye
Liu, Shupeng
Cheng, Zhongping
author_facet Liu, Li
Liu, Biting
Wang, Lian
Li, Caixia
Zhou, Yang
Zhu, Jihui
Ding, Jinye
Liu, Shupeng
Cheng, Zhongping
author_sort Liu, Li
collection PubMed
description Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn strongly correlated with ovarian reserve by using bioinformatics analysis. Aimed to investigate the validity of these candidate biomarkers for evaluating the PFP, we utilized an OR comparison model to decode the relationship between the numbers of PFP and candidate biomarkers in the present study. Our results suggest that these biomarkers Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn possess independent potential to evaluate the number of the PFP. And the combination of Sohlh1 and Lhx8 can be used as the optimal biomarkers for rapid assessment of the PFP in the murine ovary. Our findings provide a new perspective for evaluating the PFP of the ovary in animal studies and the clinic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12958-023-01097-3.
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spelling pubmed-101862932023-05-17 Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice Liu, Li Liu, Biting Wang, Lian Li, Caixia Zhou, Yang Zhu, Jihui Ding, Jinye Liu, Shupeng Cheng, Zhongping Reprod Biol Endocrinol Research Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn strongly correlated with ovarian reserve by using bioinformatics analysis. Aimed to investigate the validity of these candidate biomarkers for evaluating the PFP, we utilized an OR comparison model to decode the relationship between the numbers of PFP and candidate biomarkers in the present study. Our results suggest that these biomarkers Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn possess independent potential to evaluate the number of the PFP. And the combination of Sohlh1 and Lhx8 can be used as the optimal biomarkers for rapid assessment of the PFP in the murine ovary. Our findings provide a new perspective for evaluating the PFP of the ovary in animal studies and the clinic. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12958-023-01097-3. BioMed Central 2023-05-16 /pmc/articles/PMC10186293/ /pubmed/37194006 http://dx.doi.org/10.1186/s12958-023-01097-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Liu, Li
Liu, Biting
Wang, Lian
Li, Caixia
Zhou, Yang
Zhu, Jihui
Ding, Jinye
Liu, Shupeng
Cheng, Zhongping
Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
title Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
title_full Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
title_fullStr Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
title_full_unstemmed Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
title_short Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
title_sort sohlh1 and lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186293/
https://www.ncbi.nlm.nih.gov/pubmed/37194006
http://dx.doi.org/10.1186/s12958-023-01097-3
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