Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice

Accumulation of senescent cells (SNCs) with a senescence‐associated secretory phenotype (SASP) has been implicated as a major source of chronic sterile inflammation leading to many age‐related pathologies. Herein, we provide evidence that a bifunctional immunotherapeutic, HCW9218, with capabilities...

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Detalles Bibliográficos
Autores principales: Shrestha, Niraj, Chaturvedi, Pallavi, Zhu, Xiaoyun, Dee, Michael J., George, Varghese, Janney, Christopher, Egan, Jack O., Liu, Bai, Foster, Mark, Marsala, Lynne, Wong, Pamela, Cubitt, Celia C., Foltz, Jennifer A., Tran, Jennifer, Schappe, Timothy, Hsiao, Karin, Leclerc, Gilles M., You, Lijing, Echeverri, Christian, Spanoudis, Catherine, Carvalho, Ana, Kanakaraj, Leah, Gilkes, Crystal, Encalada, Nicole, Kong, Lin, Wang, Meng, Fang, Byron, Wang, Zheng, Jiao, Jin‐an, Muniz, Gabriela J., Jeng, Emily K., Valdivieso, Nicole, Li, Liying, Deth, Richard, Berrien‐Elliott, Melissa M., Fehniger, Todd A., Rhode, Peter R., Wong, Hing C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186597/
https://www.ncbi.nlm.nih.gov/pubmed/36967480
http://dx.doi.org/10.1111/acel.13806

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