Age‐dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution

Our studies indicate that the longevity factor SIRT1 is implicated in metabolic disease; however, whether and how hepatocyte‐specific SIRT1 signaling is involved in liver fibrosis remains undefined. We characterized a functional link of age‐mediated defects in SIRT1 to the NLRP3 inflammasome during...

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Detalles Bibliográficos
Autores principales: Adjei‐Mosi, Jennifer, Sun, Qing, Smithson, Steven Blake, Shealy, Gavyn Lee, Amerineni, Krupa Dhruvitha, Liang, Zerong, Chen, Hanqing, Wang, Mei, Ping, Qinggong, Han, Jingyan, Morita, Masahiro, Kamat, Amrita, Musi, Nicolas, Zang, Mengwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186605/
https://www.ncbi.nlm.nih.gov/pubmed/36999514
http://dx.doi.org/10.1111/acel.13811

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