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Ensheathing glia promote increased lifespan and healthy brain aging
Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage, analogous to mammalian microglia. We previously reported changes in glia composition over the life of ants and fruit flies,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186613/ https://www.ncbi.nlm.nih.gov/pubmed/36840361 http://dx.doi.org/10.1111/acel.13803 |
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author | Sheng, Lihong Shields, Emily J. Gospocic, Janko Sorida, Masato Ju, Linyang Byrns, China N. Carranza, Faith Berger, Shelley L. Bonini, Nancy Bonasio, Roberto |
author_facet | Sheng, Lihong Shields, Emily J. Gospocic, Janko Sorida, Masato Ju, Linyang Byrns, China N. Carranza, Faith Berger, Shelley L. Bonini, Nancy Bonasio, Roberto |
author_sort | Sheng, Lihong |
collection | PubMed |
description | Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage, analogous to mammalian microglia. We previously reported changes in glia composition over the life of ants and fruit flies, including a decline in the relative proportion of ensheathing glia with time. How these changes influence brain health and life expectancy is unknown. Here, we show that ensheathing glia but not astrocytes decrease in number during Drosophila melanogaster brain aging. The remaining ensheathing glia display dysregulated expression of genes involved in lipid metabolism and apoptosis, which may lead to lipid droplet accumulation, cellular dysfunction, and death. Inhibition of apoptosis rescued the decline of ensheathing glia with age, improved the neuromotor performance of aged flies, and extended lifespan. Furthermore, an expanded ensheathing glia population prevented amyloid‐beta accumulation in a fly model of Alzheimer's disease and delayed the premature death of the diseased animals. These findings suggest that ensheathing glia play a vital role in regulating brain health and animal longevity. |
format | Online Article Text |
id | pubmed-10186613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101866132023-05-17 Ensheathing glia promote increased lifespan and healthy brain aging Sheng, Lihong Shields, Emily J. Gospocic, Janko Sorida, Masato Ju, Linyang Byrns, China N. Carranza, Faith Berger, Shelley L. Bonini, Nancy Bonasio, Roberto Aging Cell Research Articles Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage, analogous to mammalian microglia. We previously reported changes in glia composition over the life of ants and fruit flies, including a decline in the relative proportion of ensheathing glia with time. How these changes influence brain health and life expectancy is unknown. Here, we show that ensheathing glia but not astrocytes decrease in number during Drosophila melanogaster brain aging. The remaining ensheathing glia display dysregulated expression of genes involved in lipid metabolism and apoptosis, which may lead to lipid droplet accumulation, cellular dysfunction, and death. Inhibition of apoptosis rescued the decline of ensheathing glia with age, improved the neuromotor performance of aged flies, and extended lifespan. Furthermore, an expanded ensheathing glia population prevented amyloid‐beta accumulation in a fly model of Alzheimer's disease and delayed the premature death of the diseased animals. These findings suggest that ensheathing glia play a vital role in regulating brain health and animal longevity. John Wiley and Sons Inc. 2023-02-24 /pmc/articles/PMC10186613/ /pubmed/36840361 http://dx.doi.org/10.1111/acel.13803 Text en © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Sheng, Lihong Shields, Emily J. Gospocic, Janko Sorida, Masato Ju, Linyang Byrns, China N. Carranza, Faith Berger, Shelley L. Bonini, Nancy Bonasio, Roberto Ensheathing glia promote increased lifespan and healthy brain aging |
title | Ensheathing glia promote increased lifespan and healthy brain aging |
title_full | Ensheathing glia promote increased lifespan and healthy brain aging |
title_fullStr | Ensheathing glia promote increased lifespan and healthy brain aging |
title_full_unstemmed | Ensheathing glia promote increased lifespan and healthy brain aging |
title_short | Ensheathing glia promote increased lifespan and healthy brain aging |
title_sort | ensheathing glia promote increased lifespan and healthy brain aging |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186613/ https://www.ncbi.nlm.nih.gov/pubmed/36840361 http://dx.doi.org/10.1111/acel.13803 |
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