Cargando…

Ensheathing glia promote increased lifespan and healthy brain aging

Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage, analogous to mammalian microglia. We previously reported changes in glia composition over the life of ants and fruit flies,...

Descripción completa

Detalles Bibliográficos
Autores principales: Sheng, Lihong, Shields, Emily J., Gospocic, Janko, Sorida, Masato, Ju, Linyang, Byrns, China N., Carranza, Faith, Berger, Shelley L., Bonini, Nancy, Bonasio, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186613/
https://www.ncbi.nlm.nih.gov/pubmed/36840361
http://dx.doi.org/10.1111/acel.13803
_version_ 1785042597747621888
author Sheng, Lihong
Shields, Emily J.
Gospocic, Janko
Sorida, Masato
Ju, Linyang
Byrns, China N.
Carranza, Faith
Berger, Shelley L.
Bonini, Nancy
Bonasio, Roberto
author_facet Sheng, Lihong
Shields, Emily J.
Gospocic, Janko
Sorida, Masato
Ju, Linyang
Byrns, China N.
Carranza, Faith
Berger, Shelley L.
Bonini, Nancy
Bonasio, Roberto
author_sort Sheng, Lihong
collection PubMed
description Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage, analogous to mammalian microglia. We previously reported changes in glia composition over the life of ants and fruit flies, including a decline in the relative proportion of ensheathing glia with time. How these changes influence brain health and life expectancy is unknown. Here, we show that ensheathing glia but not astrocytes decrease in number during Drosophila melanogaster brain aging. The remaining ensheathing glia display dysregulated expression of genes involved in lipid metabolism and apoptosis, which may lead to lipid droplet accumulation, cellular dysfunction, and death. Inhibition of apoptosis rescued the decline of ensheathing glia with age, improved the neuromotor performance of aged flies, and extended lifespan. Furthermore, an expanded ensheathing glia population prevented amyloid‐beta accumulation in a fly model of Alzheimer's disease and delayed the premature death of the diseased animals. These findings suggest that ensheathing glia play a vital role in regulating brain health and animal longevity.
format Online
Article
Text
id pubmed-10186613
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-101866132023-05-17 Ensheathing glia promote increased lifespan and healthy brain aging Sheng, Lihong Shields, Emily J. Gospocic, Janko Sorida, Masato Ju, Linyang Byrns, China N. Carranza, Faith Berger, Shelley L. Bonini, Nancy Bonasio, Roberto Aging Cell Research Articles Glia have an emergent role in brain aging and disease. In the Drosophila melanogaster brain, ensheathing glia function as phagocytic cells and respond to acute neuronal damage, analogous to mammalian microglia. We previously reported changes in glia composition over the life of ants and fruit flies, including a decline in the relative proportion of ensheathing glia with time. How these changes influence brain health and life expectancy is unknown. Here, we show that ensheathing glia but not astrocytes decrease in number during Drosophila melanogaster brain aging. The remaining ensheathing glia display dysregulated expression of genes involved in lipid metabolism and apoptosis, which may lead to lipid droplet accumulation, cellular dysfunction, and death. Inhibition of apoptosis rescued the decline of ensheathing glia with age, improved the neuromotor performance of aged flies, and extended lifespan. Furthermore, an expanded ensheathing glia population prevented amyloid‐beta accumulation in a fly model of Alzheimer's disease and delayed the premature death of the diseased animals. These findings suggest that ensheathing glia play a vital role in regulating brain health and animal longevity. John Wiley and Sons Inc. 2023-02-24 /pmc/articles/PMC10186613/ /pubmed/36840361 http://dx.doi.org/10.1111/acel.13803 Text en © 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Sheng, Lihong
Shields, Emily J.
Gospocic, Janko
Sorida, Masato
Ju, Linyang
Byrns, China N.
Carranza, Faith
Berger, Shelley L.
Bonini, Nancy
Bonasio, Roberto
Ensheathing glia promote increased lifespan and healthy brain aging
title Ensheathing glia promote increased lifespan and healthy brain aging
title_full Ensheathing glia promote increased lifespan and healthy brain aging
title_fullStr Ensheathing glia promote increased lifespan and healthy brain aging
title_full_unstemmed Ensheathing glia promote increased lifespan and healthy brain aging
title_short Ensheathing glia promote increased lifespan and healthy brain aging
title_sort ensheathing glia promote increased lifespan and healthy brain aging
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186613/
https://www.ncbi.nlm.nih.gov/pubmed/36840361
http://dx.doi.org/10.1111/acel.13803
work_keys_str_mv AT shenglihong ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT shieldsemilyj ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT gospocicjanko ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT soridamasato ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT julinyang ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT byrnschinan ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT carranzafaith ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT bergershelleyl ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT bonininancy ensheathinggliapromoteincreasedlifespanandhealthybrainaging
AT bonasioroberto ensheathinggliapromoteincreasedlifespanandhealthybrainaging