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COVID-19: A MULTI-HOST PANDEMIC

SARS-CoV-2, the causal agent of the COVID-19 pandemic, is related to a group of viruses (Sarbecovirus) that circulate in horseshoe bats. Its origin is still uncertain, as there is lack of an identifiable intermediate host species for the proximal animal ancestor of SARS-CoV-2. Irrespective of its or...

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Autor principal: Beldomenico, Pablo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186925/
http://dx.doi.org/10.1016/j.ijid.2023.04.084
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author Beldomenico, Pablo M.
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description SARS-CoV-2, the causal agent of the COVID-19 pandemic, is related to a group of viruses (Sarbecovirus) that circulate in horseshoe bats. Its origin is still uncertain, as there is lack of an identifiable intermediate host species for the proximal animal ancestor of SARS-CoV-2. Irrespective of its origin, SARS-CoV-2 has been shown to replicate in many mammalian species. So far, over forty species have been found to be susceptible to SARS-CoV-2 infection, and natural infections have been documented in at least 23 species of distant mammalian orders, including Primata, Rodentia, Carnivora, and Arthiodactyla. In two of those species, minks and white tailed deer, continued transmission among conspecifics occurred following introduction of SARS-CoV-2 from humans, at a rate which makes mink farms and deer populations suitable compartments where the virus may be maintained and evolve, and then perhaps spill back to humans or other animals as a new variant, as suggested by molecular evidence. Considering the above, what is truly unique about this pandemic, and adds a major obstacle to attain its control, is its multi-host nature. This is another compelling example of the relevance of the 'One Health' approach. This approach recognizes the inextricable links between people and nature, and visualizes the health and disease phenomenon from an integrative perspective. The COVID-19 pandemic urges us to acknowledge the interconnection between people and the remaining forms of life, and with the environments they share, and demonstrates that the improvement of global health needs a collaborative, multisectoral, and transdisciplinary approach, acting at the local, regional and global levels. This concept becomes paramount when taking into account that most diseases affecting humans in the last decades -not only COVID-19 - have been caused by pathogens originated in animals.
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spelling pubmed-101869252023-05-16 COVID-19: A MULTI-HOST PANDEMIC Beldomenico, Pablo M. Int J Infect Dis S1: One Health session: Serosurveillance of High Consequence Zoonotic Viruses at the Human-Animal InterfaceDate: Friday, Nov 18, 2022 Time: 10:30-12:00Venue: Banquet Hall Level 3 SARS-CoV-2, the causal agent of the COVID-19 pandemic, is related to a group of viruses (Sarbecovirus) that circulate in horseshoe bats. Its origin is still uncertain, as there is lack of an identifiable intermediate host species for the proximal animal ancestor of SARS-CoV-2. Irrespective of its origin, SARS-CoV-2 has been shown to replicate in many mammalian species. So far, over forty species have been found to be susceptible to SARS-CoV-2 infection, and natural infections have been documented in at least 23 species of distant mammalian orders, including Primata, Rodentia, Carnivora, and Arthiodactyla. In two of those species, minks and white tailed deer, continued transmission among conspecifics occurred following introduction of SARS-CoV-2 from humans, at a rate which makes mink farms and deer populations suitable compartments where the virus may be maintained and evolve, and then perhaps spill back to humans or other animals as a new variant, as suggested by molecular evidence. Considering the above, what is truly unique about this pandemic, and adds a major obstacle to attain its control, is its multi-host nature. This is another compelling example of the relevance of the 'One Health' approach. This approach recognizes the inextricable links between people and nature, and visualizes the health and disease phenomenon from an integrative perspective. The COVID-19 pandemic urges us to acknowledge the interconnection between people and the remaining forms of life, and with the environments they share, and demonstrates that the improvement of global health needs a collaborative, multisectoral, and transdisciplinary approach, acting at the local, regional and global levels. This concept becomes paramount when taking into account that most diseases affecting humans in the last decades -not only COVID-19 - have been caused by pathogens originated in animals. Published by Elsevier Ltd. 2023-05 2023-05-16 /pmc/articles/PMC10186925/ http://dx.doi.org/10.1016/j.ijid.2023.04.084 Text en Copyright © 2023 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle S1: One Health session: Serosurveillance of High Consequence Zoonotic Viruses at the Human-Animal InterfaceDate: Friday, Nov 18, 2022 Time: 10:30-12:00Venue: Banquet Hall Level 3
Beldomenico, Pablo M.
COVID-19: A MULTI-HOST PANDEMIC
title COVID-19: A MULTI-HOST PANDEMIC
title_full COVID-19: A MULTI-HOST PANDEMIC
title_fullStr COVID-19: A MULTI-HOST PANDEMIC
title_full_unstemmed COVID-19: A MULTI-HOST PANDEMIC
title_short COVID-19: A MULTI-HOST PANDEMIC
title_sort covid-19: a multi-host pandemic
topic S1: One Health session: Serosurveillance of High Consequence Zoonotic Viruses at the Human-Animal InterfaceDate: Friday, Nov 18, 2022 Time: 10:30-12:00Venue: Banquet Hall Level 3
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10186925/
http://dx.doi.org/10.1016/j.ijid.2023.04.084
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