Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds–synthesis, biological activity, and structural evaluation

Schizophrenia is a chronic mental disorder that is not satisfactorily treated with available antipsychotics. The presented study focuses on the search for new antipsychotics by optimising the compound D2AAK3, a multi-target ligand of G-protein-coupled receptors (GPCRs), in particular D(2), 5-HT(1A),...

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Detalles Bibliográficos
Autores principales: Stępnicki, Piotr, Wronikowska-Denysiuk, Olga, Zięba, Agata, Targowska-Duda, Katarzyna M., Bartyzel, Agata, Wróbel, Martyna Z., Wróbel, Tomasz M., Szałaj, Klaudia, Chodkowski, Andrzej, Mirecka, Karolina, Budzyńska, Barbara, Fornal, Emilia, Turło, Jadwiga, Castro, Marián, Kaczor, Agnieszka A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187112/
https://www.ncbi.nlm.nih.gov/pubmed/37184096
http://dx.doi.org/10.1080/14756366.2023.2209828

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