Synergistic Binding of the Halide and Cationic Prime Substrate of the l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States

An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl(−) or Br(−)), the halogenation target (“prime substrate”), and dioxygen. In well-studied cases, the three non-gaseous substrates must bind to activate the enzyme’s Fe(II) cofactor for efficient capture of O(2). Halide...

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Detalles Bibliográficos
Autores principales: Slater, Jeffrey W., Neugebauer, Monica E., McBride, Molly J., Sil, Debangsu, Lin, Chi-Yun, Katch, Bryce J., Boal, Amie K., Chang, Michelle C.Y., Silakov, Alexey, Krebs, Carsten, Bollinger, J. Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187165/
https://www.ncbi.nlm.nih.gov/pubmed/37205437
http://dx.doi.org/10.1101/2023.05.02.539147

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