Cargando…

Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity

Progress in cytokine engineering is driving therapeutic translation by overcoming the inherent limitations of these proteins as drugs. The interleukin-2 (IL-2) cytokine harbors great promise as an immune stimulant for cancer treatment. However, the cytokine’s concurrent activation of both pro-inflam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Leonard, Elissa K., Tomala, Jakub, Gould, Joseph R., Leff, Michael I., Lin, Jian-Xin, Li, Peng, Porter, Mitchell J., Johansen, Eric R., Thompson, Ladaisha, Cao, Shanelle D., Henclova, Tereza, Huliciak, Maros, Vaněk, Ondřej, Kovar, Marek, Leonard, Warren J., Spangler, Jamie B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187205/ https://www.ncbi.nlm.nih.gov/pubmed/37205604 http://dx.doi.org/10.1101/2023.05.03.539272

Ejemplares similares

Protein Binder (ProBi) as a New Class of Structurally Robust Non-Antibody Protein Scaffold for Directed Evolution
por: Pham, Phuong Ngoc, et al.
Publicado: (2021)

Antibody–Invertase Fusion Protein Enables Quantitative Detection of SARS-CoV-2 Antibodies Using Widely Available Glucometers
por: Leonard, Elissa K., et al.
Publicado: (2022)

Evaluation of the Potency of Anti-HIV and Anti-HCV Drugs to Inhibit P-Glycoprotein Mediated Efflux of Digoxin in Caco-2 Cell Line and Human Precision-Cut Intestinal Slices
por: Huličiak, Martin, et al.
Publicado: (2022)

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection
por: VanDyke, Derek, et al.
Publicado: (2022)

IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25(+)Foxp3(-) T cells
por: Tomala, Jakub, et al.
Publicado: (2021)

Pro Hibernate and MongoDB
por: Leonard, Anghel
Publicado: (2013)

Pro Java 7 NIO.2
por: Leonard, Anghel
Publicado: (2011)

Phlebotomus perniciosus Recombinant Salivary Proteins Polarize Murine Macrophages Toward the Anti-Inflammatory Phenotype
por: Sumova, Petra, et al.
Publicado: (2020)

Pro: Integrated Five-Year Anesthesiology Residency Should Be Implemented Widely
por: Kovar, Alan J., et al.
Publicado: (2023)

Percutaneous endoscopic cecostomy for management of Ogilvie’s syndrome: a case series and literature review with an update on current guidelines (with video)
por: Vanek, Petr, et al.
Publicado: (2023)

Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes
por: Klimova, Nela, et al.
Publicado: (2022)

Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states
por: Skálová, Tereza, et al.
Publicado: (2015)

Influence of Elevation Data Resolution on Spatial Prediction of Colluvial Soils in a Luvisol Region
por: Penížek, Vít, et al.
Publicado: (2016)

ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity
por: Radonova, Lenka, et al.
Publicado: (2019)

In vitro antitumor, pro-inflammatory, and pro-coagulant activities of Megalopyge opercularis J.E. Smith hemolymph and spine venom
por: Orozco-Flores, Alonso A., et al.
Publicado: (2020)

Chemical process control: theory and applications
por: Gould, Leonard A
Publicado: (1969)

Supramolecular filaments for concurrent ACE2 docking and enzymatic activity silencing enable coronavirus capture and infection prevention
por: Anderson, Caleb F., et al.
Publicado: (2023)

Current Screening Strategies for Pancreatic Cancer
por: Vanek, Petr, et al.
Publicado: (2022)

SOT101 induces NK cell cytotoxicity and potentiates antibody-dependent cell cytotoxicity and anti-tumor activity
por: Antosova, Zuzana, et al.
Publicado: (2022)

Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation
por: Skořepa, Ondřej, et al.
Publicado: (2020)

Joined at the hip: The role of light chain complementarity determining region 2 in antibody self-association
por: Sargunas, Paul R., et al.
Publicado: (2022)

The Pro-tumorigenic IL-33 Involved in Antitumor Immunity: A Yin and Yang Cytokine
por: Fournié, Jean-Jacques, et al.
Publicado: (2018)

Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration
por: Saragovi, Horacio Uri, et al.
Publicado: (2019)

Next generation sequencing reveals a novel nonsense mutation in MSX1 gene related to oligodontia
por: Bonczek, Ondřej, et al.
Publicado: (2018)

Field study of the improved rapid sand fly exposure test in areas endemic for canine leishmaniasis
por: Willen, Laura, et al.
Publicado: (2019)

Disconnected pancreatic duct syndrome in patients with necrotizing pancreatitis
por: Vanek, Petr, et al.
Publicado: (2022)

A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma
por: Kaps, Leonard, et al.
Publicado: (2023)

THE PRESENCE OF RENIN ACTIVITY IN BLOOD VESSEL WALLS
por: Gould, Anne B., et al.
Publicado: (1964)

Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable?
por: Shillingford, Shanelle R., et al.
Publicado: (2023)

Antitumoral Drug-Loaded Biocompatible Polymeric Nanoparticles Obtained by Non-Aqueous Emulsion Polymerization
por: Daraba, Oana Maria, et al.
Publicado: (2020)

Rifampicin Induces Gene, Protein, and Activity of P-Glycoprotein (ABCB1) in Human Precision-Cut Intestinal Slices
por: Martinec, Ondrej, et al.
Publicado: (2021)

Chemical composition, in vitro antitumor and pro-oxidant activities of Glandora rosmarinifolia (Boraginaceae) essential oil
por: Poma, Paola, et al.
Publicado: (2018)

Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance
por: Farsa, Oldřich, et al.
Publicado: (2022)

The Management of Sleep Disturbances in Patients with Schizophrenia: A Case Series
por: Vanek, Jakub, et al.
Publicado: (2022)

Mild steel and stainless steel welding fumes elicit pro‐inflammatory and pro‐oxidant effects in first trimester trophoblast cells
por: Olgun, Nicole S., et al.
Publicado: (2020)

Study of tumor growth indicates the existence of an “immunological threshold” separating states of pro- and antitumoral peritumoral inflammation
por: Brú, Antonio, et al.
Publicado: (2018)

New fluorobenzamidine exerts antitumor activity against breast cancer in mice via pro-apoptotic activity
por: Saleh, AbdelRahman B., et al.
Publicado: (2022)

Bordetella Adenylate Cyclase Toxin Differentially Modulates Toll-Like Receptor-Stimulated Activation, Migration and T Cell Stimulatory Capacity of Dendritic Cells
por: Adkins, Irena, et al.
Publicado: (2014)

Mindfulness Meditation Interventions for Long COVID: Biobehavioral Gene Expression and Neuroimmune Functioning
por: Porter, Nicole, et al.
Publicado: (2022)

Investigation of Molten Metal Infiltration into Micropore Carbon Refractory Materials Using X-ray Computed Tomography
por: Stec, Jakub, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_liaijm8tdgtnjdq1gv9gra6v6d