CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms

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Multidrug resistance (MDR) transporters such as ATP Binding Cassette (ABC) and Major Facilitator Superfamily (MFS) proteins are important mediators of antifungal drug resistance, particularly with respect to azole class drugs. Consequently, identifying molecules that are not susceptible to this mech...

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Detalles Bibliográficos
Autores principales: Miron-Ocampo, Aracely, Beattie, Sarah R., Guin, Soumitra, Conway, Thomas, Meyers, Marvin J., Moye-Rowley, W. Scott, Krysan, Damian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187223/
https://www.ncbi.nlm.nih.gov/pubmed/37205554
http://dx.doi.org/10.1101/2023.05.01.538946
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