Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...

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Detalles Bibliográficos
Autores principales: Hofman, Damon A., Ruiz-Orera, Jorge, Yannuzzi, Ian, Murugesan, Rakesh, Brown, Adam, Clauser, Karl R., Condurat, Alexandra L., van Dinter, Jip T., Engels, Sem A.G., Goodale, Amy, van der Lugt, Jasper, Abid, Tanaz, Wang, Li, Zhou, Kevin N., Vogelzang, Jayne, Ligon, Keith L., Phoenix, Timothy N., Roth, Jennifer A., Root, David E., Hubner, Norbert, Golub, Todd R., Bandopadhayay, Pratiti, van Heesch, Sebastiaan, Prensner, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187264/
https://www.ncbi.nlm.nih.gov/pubmed/37205492
http://dx.doi.org/10.1101/2023.05.04.539399

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