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Amyloid pathology impairs experience-dependent inhibitory synaptic plasticity

Alzheimer’s disease patients and mouse models exhibit aberrant neuronal activity and altered excitatory-to-inhibitory synaptic ratio. Using multicolor two-photon microscopy, we test how amyloid pathology alters the structural dynamics of excitatory and inhibitory synapses and their adaptation to alt...

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Detalles Bibliográficos
Autores principales: Niraula, Suraj, Yan, Shirley ShiDu, Subramanian, Jaichandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187277/
https://www.ncbi.nlm.nih.gov/pubmed/37205469
http://dx.doi.org/10.1101/2023.05.04.539450