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No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease

BACKGROUND: Approximately one third of recently diagnosed Parkinson’s disease (PD) patients experience cognitive decline. The nucleus basalis of Meynert (NBM) degenerates early in PD and is crucial for cognitive function. The two main NBM white matter pathways include a lateral and medial trajectory...

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Autores principales: Crockett, Rachel A., Wilkins, Kevin B., Aditham, Sudeep, Brontë-Stewart, Helen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187344/
https://www.ncbi.nlm.nih.gov/pubmed/37205443
http://dx.doi.org/10.1101/2023.05.01.23289348
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author Crockett, Rachel A.
Wilkins, Kevin B.
Aditham, Sudeep
Brontë-Stewart, Helen M.
author_facet Crockett, Rachel A.
Wilkins, Kevin B.
Aditham, Sudeep
Brontë-Stewart, Helen M.
author_sort Crockett, Rachel A.
collection PubMed
description BACKGROUND: Approximately one third of recently diagnosed Parkinson’s disease (PD) patients experience cognitive decline. The nucleus basalis of Meynert (NBM) degenerates early in PD and is crucial for cognitive function. The two main NBM white matter pathways include a lateral and medial trajectory. However, research is needed to determine which pathway, if any, are associated with PD-related cognitive decline. METHODS: Thirty-seven PD patients with no mild cognitive impairment (MCI) were included in this study. Participants either developed MCI at 1-year follow up (PD MCI-Converters; n=16) or did not (PD no-MCI; n=21). Mean diffusivity (MD) of the medial and lateral NBM tracts were extracted using probabilistic tractography. Between-group differences in MD for each tract was compared using ANCOVA, controlling for age, sex, and disease duration. Control comparisons of the internal capsule MD were also performed. Associations between baseline MD and cognitive outcomes (working memory, psychomotor speed, delayed recall, and visuospatial function) were assessed using linear mixed models. RESULTS: PD MCI-Converters had significantly greater MD of both NBM tracts compared to PD no-MCI (p<.001). No difference was found in the control region (p=.06). Trends were identified between: 1) lateral tract MD, poorer visuospatial performance (p=.05) and working memory decline (p=.04); and 2) medial tract MD and reduced psychomotor speed (p=.03). CONCLUSIONS: Reduced integrity of the NBM tracts is evident in PD patients up to one year prior to the development of MCI. Thus, deterioration of the NBM tracts in PD may be an early marker of those at risk of cognitive decline.
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spelling pubmed-101873442023-05-17 No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease Crockett, Rachel A. Wilkins, Kevin B. Aditham, Sudeep Brontë-Stewart, Helen M. medRxiv Article BACKGROUND: Approximately one third of recently diagnosed Parkinson’s disease (PD) patients experience cognitive decline. The nucleus basalis of Meynert (NBM) degenerates early in PD and is crucial for cognitive function. The two main NBM white matter pathways include a lateral and medial trajectory. However, research is needed to determine which pathway, if any, are associated with PD-related cognitive decline. METHODS: Thirty-seven PD patients with no mild cognitive impairment (MCI) were included in this study. Participants either developed MCI at 1-year follow up (PD MCI-Converters; n=16) or did not (PD no-MCI; n=21). Mean diffusivity (MD) of the medial and lateral NBM tracts were extracted using probabilistic tractography. Between-group differences in MD for each tract was compared using ANCOVA, controlling for age, sex, and disease duration. Control comparisons of the internal capsule MD were also performed. Associations between baseline MD and cognitive outcomes (working memory, psychomotor speed, delayed recall, and visuospatial function) were assessed using linear mixed models. RESULTS: PD MCI-Converters had significantly greater MD of both NBM tracts compared to PD no-MCI (p<.001). No difference was found in the control region (p=.06). Trends were identified between: 1) lateral tract MD, poorer visuospatial performance (p=.05) and working memory decline (p=.04); and 2) medial tract MD and reduced psychomotor speed (p=.03). CONCLUSIONS: Reduced integrity of the NBM tracts is evident in PD patients up to one year prior to the development of MCI. Thus, deterioration of the NBM tracts in PD may be an early marker of those at risk of cognitive decline. Cold Spring Harbor Laboratory 2023-05-02 /pmc/articles/PMC10187344/ /pubmed/37205443 http://dx.doi.org/10.1101/2023.05.01.23289348 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Crockett, Rachel A.
Wilkins, Kevin B.
Aditham, Sudeep
Brontë-Stewart, Helen M.
No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease
title No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease
title_full No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease
title_fullStr No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease
title_full_unstemmed No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease
title_short No Laughing White Matter: Cortical Cholinergic Pathways and Cognitive Decline in Parkinson’s Disease
title_sort no laughing white matter: cortical cholinergic pathways and cognitive decline in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187344/
https://www.ncbi.nlm.nih.gov/pubmed/37205443
http://dx.doi.org/10.1101/2023.05.01.23289348
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