Task-induced changes in brain entropy

Entropy indicates irregularity of a dynamic system with higher entropy indicating higher irregularity and more transit states. In the human brain, regional entropy has been increasingly assessed using resting state fMRI. Response of regional entropy to task has been scarcely studied. The purpose of this study is to characterize task-induced regional brain entropy (BEN) alterations using the large Human Connectome Project (HCP) data. To control the potential modulation by the block-design, BEN of task-fMRI was calculated from the fMRI images acquired during the task conditions only and then compared to BEN of rsfMRI. Compared to resting state, task-performance unanimously induced BEN reduction in the peripheral cortical area including both the task activated regions and task non-specific regions such as the task negative area and BEN increase in the centric part of the sensorimotor and perception networks. Task control condition showed large residual task effects. After controlling the task non-specific effects using the control BEN vs task BEN comparison, regional BEN showed task specific effects in target regions.