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Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study

BACKGROUND: Studies have suggested the potential roles of serum trace elements such as calcium and magnesium in the development of uterine fibroids. AIMS: This study compared magnesium and calcium serum levels in reproductive-age women with and without uterine fibroids in Lagos, Southwest Nigeria. M...

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Autores principales: ADEBOJE-JIMOH, Fatimah, OKUNADE, Kehinde Sharafadeen, OLORUNFEMI, Gbenga, OLAMIJULO, Joseph Ayodeji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187406/
https://www.ncbi.nlm.nih.gov/pubmed/37205458
http://dx.doi.org/10.21203/rs.3.rs-2877359/v1
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author ADEBOJE-JIMOH, Fatimah
OKUNADE, Kehinde Sharafadeen
OLORUNFEMI, Gbenga
OLAMIJULO, Joseph Ayodeji
author_facet ADEBOJE-JIMOH, Fatimah
OKUNADE, Kehinde Sharafadeen
OLORUNFEMI, Gbenga
OLAMIJULO, Joseph Ayodeji
author_sort ADEBOJE-JIMOH, Fatimah
collection PubMed
description BACKGROUND: Studies have suggested the potential roles of serum trace elements such as calcium and magnesium in the development of uterine fibroids. AIMS: This study compared magnesium and calcium serum levels in reproductive-age women with and without uterine fibroids in Lagos, Southwest Nigeria. METHODS: A comparative cross-sectional study of 194 parity-matched women with or without a sonographic diagnosis of uterine fibroids enrolled at a university teaching hospital in Lagos, Southwest Nigeria. Participants’ sociodemographic, ultrasound, and anthropometric information as well as the estimated serum levels of calcium and magnesium were collected for statistical analyses. RESULTS: This study found significant negative associations between low serum calcium levels and uterine fibroids (adjusted odds ratio= 0.06; 95% CI: 0.004, 0.958; p=0.047), uterine size (p=0.004), and the number of fibroid nodules (p=0.030). However, no significant association was observed between serum magnesium levels and uterine fibroids (p=0.341). CONCLUSION: The findings of this study suggest the promising role of calcium-rich diets and supplements in the prevention of uterine fibroids among Nigerian women. However, future longitudinal studies are required to further evaluate the potential role of these trace mineral elements in the development of uterine fibroids.
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spelling pubmed-101874062023-05-17 Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study ADEBOJE-JIMOH, Fatimah OKUNADE, Kehinde Sharafadeen OLORUNFEMI, Gbenga OLAMIJULO, Joseph Ayodeji Res Sq Article BACKGROUND: Studies have suggested the potential roles of serum trace elements such as calcium and magnesium in the development of uterine fibroids. AIMS: This study compared magnesium and calcium serum levels in reproductive-age women with and without uterine fibroids in Lagos, Southwest Nigeria. METHODS: A comparative cross-sectional study of 194 parity-matched women with or without a sonographic diagnosis of uterine fibroids enrolled at a university teaching hospital in Lagos, Southwest Nigeria. Participants’ sociodemographic, ultrasound, and anthropometric information as well as the estimated serum levels of calcium and magnesium were collected for statistical analyses. RESULTS: This study found significant negative associations between low serum calcium levels and uterine fibroids (adjusted odds ratio= 0.06; 95% CI: 0.004, 0.958; p=0.047), uterine size (p=0.004), and the number of fibroid nodules (p=0.030). However, no significant association was observed between serum magnesium levels and uterine fibroids (p=0.341). CONCLUSION: The findings of this study suggest the promising role of calcium-rich diets and supplements in the prevention of uterine fibroids among Nigerian women. However, future longitudinal studies are required to further evaluate the potential role of these trace mineral elements in the development of uterine fibroids. American Journal Experts 2023-05-04 /pmc/articles/PMC10187406/ /pubmed/37205458 http://dx.doi.org/10.21203/rs.3.rs-2877359/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. https://creativecommons.org/licenses/by/4.0/License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
ADEBOJE-JIMOH, Fatimah
OKUNADE, Kehinde Sharafadeen
OLORUNFEMI, Gbenga
OLAMIJULO, Joseph Ayodeji
Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study
title Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study
title_full Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study
title_fullStr Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study
title_full_unstemmed Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study
title_short Serum Calcium and Magnesium Levels in Women with Uterine Fibroids at a University Teaching Hospital in Southwest Nigeria: A Comparative Cross-Sectional Study
title_sort serum calcium and magnesium levels in women with uterine fibroids at a university teaching hospital in southwest nigeria: a comparative cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187406/
https://www.ncbi.nlm.nih.gov/pubmed/37205458
http://dx.doi.org/10.21203/rs.3.rs-2877359/v1
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