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Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by the presence of proteinaceous alpha-synuclein (α-syn) inclusions (Lewy bodies), markers of neuroinflammation and the progressive loss of nigrostriatal dopamine (DA) neurons. These pathological features can...

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Detalles Bibliográficos
Autores principales:	Stoll, Anna C., Kemp, Christopher J., Patterson, Joseph R., Kubik, Michael, Kuhn, Nathan, Benskey, Matthew, Duffy, Megan F., Luk, Kelvin, Sortwell, Caryl E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187424/ https://www.ncbi.nlm.nih.gov/pubmed/37205534 http://dx.doi.org/10.21203/rs.3.rs-2890683/v1

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