Opportunities and limitations of genomics for diagnosing bedaquiline-resistant tuberculosis: an individual isolate metaanalysis

BACKGROUND: Clinical bedaquiline resistance predominantly involves mutations in mmpR5 (Rv0678). However, mmpR5 resistance-associated variants (RAVs) have a variable relationship with phenotypic M. tuberculosis resistance. We performed a systematic review to (1) assess the maximal sensitivity of sequ...

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Detalles Bibliográficos
Autores principales: Nimmo, Camus, Bionghi, Neda, Cummings, Matthew J., Perumal, Rubeshan, Hopson, Madeleine, Al Jubaer, Shamim, Wolf, Allison, Mathema, Barun, Larsen, Michelle H., O’Donnell, Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187448/
https://www.ncbi.nlm.nih.gov/pubmed/37205550
http://dx.doi.org/10.1101/2023.05.04.23289023

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