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TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
TGF-β induces senescence in embryonic tissues. Whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence immune checkpoint inhibitor (ICI) responses are unknown. W...
Autores principales: | Matsuda, Satoru, Revandkar, Ajinkya, Dubash, Taronish D., Ravi, Arvind, Wittner, Ben S., Lin, Maoxuan, Morris, Robert, Burr, Risa, Guo, Hongshan, Seeger, Karsen, Szabolcs, Annamaria, Che, Dante, Nieman, Linda, Getz, Gad A., Ting, David T., Lawrence, Michael S., Gainor, Justin, Haber, Daniel A., Maheswaran, Shyamala |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187541/ https://www.ncbi.nlm.nih.gov/pubmed/36821441 http://dx.doi.org/10.1016/j.celrep.2023.112129 |
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