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FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences
In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
University of Zagreb Faculty of Food Technology and Biotechnology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187569/ https://www.ncbi.nlm.nih.gov/pubmed/37200795 http://dx.doi.org/10.17113/ftb.61.01.23.7594 |
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author | Popović, Ana-Marija Huđek Turković, Ana Žuna, Kristina Bačun-Družina, Višnja Rubelj, Ivica Matovinović, Martina |
author_facet | Popović, Ana-Marija Huđek Turković, Ana Žuna, Kristina Bačun-Družina, Višnja Rubelj, Ivica Matovinović, Martina |
author_sort | Popović, Ana-Marija |
collection | PubMed |
description | In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigenetic influence on the FTO gene as a new approach in the treatment and management of obesity. Several known substances have a positive effect on reducing FTO expression. Depending on which variant of the single nucleotide polymorphism (SNP) is present, the profile and level of gene expression changes. Implementation of environmental change measures could lead to reduced phenotypic manifestation of FTO expression. Treating obesity through FTO gene regulation will have to include various complex signal pathways in which FTO takes part. Identification of FTO gene polymorphisms may be useful for the development of individual obesity management strategies, including the recommendation of taking certain foods and supplements. |
format | Online Article Text |
id | pubmed-10187569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | University of Zagreb Faculty of Food Technology and Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-101875692023-05-17 FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences Popović, Ana-Marija Huđek Turković, Ana Žuna, Kristina Bačun-Družina, Višnja Rubelj, Ivica Matovinović, Martina Food Technol Biotechnol Minireviews In this review, we summarize the current state of knowledge on the fat mass and obesity-associated (FTO) gene and its role in obesity. The FTO-encoded protein is involved in multiple molecular pathways contributing to obesity as well as other metabolic complexities. This review emphasizes the epigenetic influence on the FTO gene as a new approach in the treatment and management of obesity. Several known substances have a positive effect on reducing FTO expression. Depending on which variant of the single nucleotide polymorphism (SNP) is present, the profile and level of gene expression changes. Implementation of environmental change measures could lead to reduced phenotypic manifestation of FTO expression. Treating obesity through FTO gene regulation will have to include various complex signal pathways in which FTO takes part. Identification of FTO gene polymorphisms may be useful for the development of individual obesity management strategies, including the recommendation of taking certain foods and supplements. University of Zagreb Faculty of Food Technology and Biotechnology 2023-03 /pmc/articles/PMC10187569/ /pubmed/37200795 http://dx.doi.org/10.17113/ftb.61.01.23.7594 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Minireviews Popović, Ana-Marija Huđek Turković, Ana Žuna, Kristina Bačun-Družina, Višnja Rubelj, Ivica Matovinović, Martina FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
title | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
title_full | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
title_fullStr | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
title_full_unstemmed | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
title_short | FTO Gene Polymorphisms at the Crossroads of Metabolic Pathways of Obesity and Epigenetic Influences |
title_sort | fto gene polymorphisms at the crossroads of metabolic pathways of obesity and epigenetic influences |
topic | Minireviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187569/ https://www.ncbi.nlm.nih.gov/pubmed/37200795 http://dx.doi.org/10.17113/ftb.61.01.23.7594 |
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