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Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease

OBJECTIVE: To compute penetrance and recurrence risk using a genome‐wide PRS (including and excluding the APOE region) in families with Alzheimer's disease. METHODS: Genotypes from the National Institute on Aging Late‐Onset Alzheimer's Disease Family‐Based Study and a study of familial Alz...

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Detalles Bibliográficos
Autores principales:	Qiao, Min, Lee, Annie J., Reyes‐Dumeyer, Dolly, Tosto, Giuseppe, Faber, Kelley, Goate, Alison, Renton, Alan, Chao, Michael, Boeve, Brad, Cruchaga, Carlos, Pericak‐Vance, Margaret, Haines, Jonathan L., Rosenberg, Roger, Tsuang, Debby, Sweet, Robert A., Bennett, David A., Wilson, Robert S., Foroud, Tatiana, Mayeux, Richard, Vardarajan, Badri N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187719/ https://www.ncbi.nlm.nih.gov/pubmed/36946865 http://dx.doi.org/10.1002/acn3.51757

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