Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report

Infant‐type hemispheric glioma, a new subtype of pediatric high‐grade glioma, arises in the cerebral hemispheres. Despite better survival outcomes, the treatment of infant‐type hemispheric glioma is still facing challenges. Here, we reported a case of QKI‐ALK fusion, infant‐type hemispheric glioma w...

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Autores principales: Lai, Mingyao, Li, Shaoqun, Li, Hainan, Hu, Qingjun, Li, Juan, Zhou, Jiangfen, Ai, Ruyu, Zhen, Junjie, Zhou, Zhaoming, Wang, Lichao, Zhang, Yangqiong, Hu, Wanming, Yuan, Li, Ma, Xuejiao, Zhang, Xing, Song, Chao, Li, Zhi, Cai, Linbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187722/
https://www.ncbi.nlm.nih.gov/pubmed/37000961
http://dx.doi.org/10.1002/acn3.51766
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author Lai, Mingyao
Li, Shaoqun
Li, Hainan
Hu, Qingjun
Li, Juan
Zhou, Jiangfen
Ai, Ruyu
Zhen, Junjie
Zhou, Zhaoming
Wang, Lichao
Zhang, Yangqiong
Hu, Wanming
Yuan, Li
Ma, Xuejiao
Zhang, Xing
Song, Chao
Li, Zhi
Cai, Linbo
author_facet Lai, Mingyao
Li, Shaoqun
Li, Hainan
Hu, Qingjun
Li, Juan
Zhou, Jiangfen
Ai, Ruyu
Zhen, Junjie
Zhou, Zhaoming
Wang, Lichao
Zhang, Yangqiong
Hu, Wanming
Yuan, Li
Ma, Xuejiao
Zhang, Xing
Song, Chao
Li, Zhi
Cai, Linbo
author_sort Lai, Mingyao
collection PubMed
description Infant‐type hemispheric glioma, a new subtype of pediatric high‐grade glioma, arises in the cerebral hemispheres. Despite better survival outcomes, the treatment of infant‐type hemispheric glioma is still facing challenges. Here, we reported a case of QKI‐ALK fusion, infant‐type hemispheric glioma with lung metastasis who achieved a complete clinical response after lorlatinib treatment. This typical case demonstrated the importance of appropriate molecularly targeted treatments in ALK‐fused tumors, and lorlatinib may serve as an effective complement to conventional chemotherapy and radiotherapy in primary glioma harboring ALK fusions and its metastasis.
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spelling pubmed-101877222023-05-17 Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report Lai, Mingyao Li, Shaoqun Li, Hainan Hu, Qingjun Li, Juan Zhou, Jiangfen Ai, Ruyu Zhen, Junjie Zhou, Zhaoming Wang, Lichao Zhang, Yangqiong Hu, Wanming Yuan, Li Ma, Xuejiao Zhang, Xing Song, Chao Li, Zhi Cai, Linbo Ann Clin Transl Neurol Case Study Infant‐type hemispheric glioma, a new subtype of pediatric high‐grade glioma, arises in the cerebral hemispheres. Despite better survival outcomes, the treatment of infant‐type hemispheric glioma is still facing challenges. Here, we reported a case of QKI‐ALK fusion, infant‐type hemispheric glioma with lung metastasis who achieved a complete clinical response after lorlatinib treatment. This typical case demonstrated the importance of appropriate molecularly targeted treatments in ALK‐fused tumors, and lorlatinib may serve as an effective complement to conventional chemotherapy and radiotherapy in primary glioma harboring ALK fusions and its metastasis. John Wiley and Sons Inc. 2023-03-31 /pmc/articles/PMC10187722/ /pubmed/37000961 http://dx.doi.org/10.1002/acn3.51766 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Study
Lai, Mingyao
Li, Shaoqun
Li, Hainan
Hu, Qingjun
Li, Juan
Zhou, Jiangfen
Ai, Ruyu
Zhen, Junjie
Zhou, Zhaoming
Wang, Lichao
Zhang, Yangqiong
Hu, Wanming
Yuan, Li
Ma, Xuejiao
Zhang, Xing
Song, Chao
Li, Zhi
Cai, Linbo
Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
title Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
title_full Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
title_fullStr Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
title_full_unstemmed Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
title_short Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
title_sort lorlatinib for alk‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187722/
https://www.ncbi.nlm.nih.gov/pubmed/37000961
http://dx.doi.org/10.1002/acn3.51766
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