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Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase

Screening children with obesity for nonalcoholic fatty liver disease leads to identification of elevated alanine aminotransferase (ALT) and is a common cause for referral to pediatric gastroenterology. Guidelines recommend that children with positive screening ALT be evaluated for causes of ALT elev...

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Autores principales: Hildreth, Amber, Shapiro, Warren L., Lowenthal, Brett M., Goyal, Anurag, Schwimmer, Jeffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187841/
https://www.ncbi.nlm.nih.gov/pubmed/37200725
http://dx.doi.org/10.1097/PG9.0000000000000292
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author Hildreth, Amber
Shapiro, Warren L.
Lowenthal, Brett M.
Goyal, Anurag
Schwimmer, Jeffrey B.
author_facet Hildreth, Amber
Shapiro, Warren L.
Lowenthal, Brett M.
Goyal, Anurag
Schwimmer, Jeffrey B.
author_sort Hildreth, Amber
collection PubMed
description Screening children with obesity for nonalcoholic fatty liver disease leads to identification of elevated alanine aminotransferase (ALT) and is a common cause for referral to pediatric gastroenterology. Guidelines recommend that children with positive screening ALT be evaluated for causes of ALT elevation beyond nonalcoholic fatty liver disease. One clinical challenge is that autoantibodies can be present in patients with obesity and thus may or may not represent autoimmune hepatitis. This case series highlights the importance of a comprehensive evaluation to reach an accurate diagnosis.
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spelling pubmed-101878412023-05-17 Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase Hildreth, Amber Shapiro, Warren L. Lowenthal, Brett M. Goyal, Anurag Schwimmer, Jeffrey B. JPGN Rep Case Report Screening children with obesity for nonalcoholic fatty liver disease leads to identification of elevated alanine aminotransferase (ALT) and is a common cause for referral to pediatric gastroenterology. Guidelines recommend that children with positive screening ALT be evaluated for causes of ALT elevation beyond nonalcoholic fatty liver disease. One clinical challenge is that autoantibodies can be present in patients with obesity and thus may or may not represent autoimmune hepatitis. This case series highlights the importance of a comprehensive evaluation to reach an accurate diagnosis. Lippincott Williams & Wilkins, Inc. 2023-02-28 /pmc/articles/PMC10187841/ /pubmed/37200725 http://dx.doi.org/10.1097/PG9.0000000000000292 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Hildreth, Amber
Shapiro, Warren L.
Lowenthal, Brett M.
Goyal, Anurag
Schwimmer, Jeffrey B.
Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase
title Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase
title_full Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase
title_fullStr Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase
title_full_unstemmed Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase
title_short Distinguishing Autoimmune Hepatitis From Steatohepatitis in Adolescents With Obesity and Positive Screening Alanine Aminotransferase
title_sort distinguishing autoimmune hepatitis from steatohepatitis in adolescents with obesity and positive screening alanine aminotransferase
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187841/
https://www.ncbi.nlm.nih.gov/pubmed/37200725
http://dx.doi.org/10.1097/PG9.0000000000000292
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