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Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience

To evaluate the ordering practices of celiac disease (CD) serologies by providers at a tertiary, academic, Children’s Hospital and compare them to guidelines and best practices. METHODS: We analyzed celiac serologies ordered in 2018 by provider type (pediatric gastrointestinal (GI) specialists, prim...

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Autores principales: Chugh, Ankur, Lo, Stanley F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187855/
https://www.ncbi.nlm.nih.gov/pubmed/37200734
http://dx.doi.org/10.1097/PG9.0000000000000302
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author Chugh, Ankur
Lo, Stanley F.
author_facet Chugh, Ankur
Lo, Stanley F.
author_sort Chugh, Ankur
collection PubMed
description To evaluate the ordering practices of celiac disease (CD) serologies by providers at a tertiary, academic, Children’s Hospital and compare them to guidelines and best practices. METHODS: We analyzed celiac serologies ordered in 2018 by provider type (pediatric gastrointestinal (GI) specialists, primary care providers (PCPs), and nonpediatric GI specialists), and identified causes for variability and nonadherence. RESULTS: The antitissue transglutaminase antibody (tTG) IgA was ordered (n = 2504) most frequently by gastroenterologists (43%), endocrinologists (22%), and other (35%). Total IgA was ordered with tTG IgA for screening purposes in 81% of overall cases, but endocrinologists ordered it only 49% of the time. The tTG IgG was ordered infrequently (1.9%) compared with tTG IgA. Antideaminated gliadin peptide (DGP) IgA/IgG levels were also infrequently ordered (5.4%) compared with tTG IgA. The antiendomysial antibody was ordered sparingly (0.9%) compared with tTG IgA, but appropriately by providers with expertise in CD, similar to ordering for celiac genetics (0.8%). Of the celiac genetic tests, 15% were ordered in error. The positivity rate of the tTG IgA ordered by PCPs was 4.4%. CONCLUSIONS: The tTG IgA was appropriately ordered by all types of providers. Endocrinologists inconsistently ordered total IgA levels with screening labs. DGP IgA/IgG tests were not commonly ordered but were inappropriately ordered by one provider. The low number of ordered antiendomysial antibody and celiac genetic tests suggests under-utilization of the nonbiopsy approach. The positive yield of tTG IgA ordered by PCPs was higher compared with previous studies.
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spelling pubmed-101878552023-05-17 Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience Chugh, Ankur Lo, Stanley F. JPGN Rep Original Article To evaluate the ordering practices of celiac disease (CD) serologies by providers at a tertiary, academic, Children’s Hospital and compare them to guidelines and best practices. METHODS: We analyzed celiac serologies ordered in 2018 by provider type (pediatric gastrointestinal (GI) specialists, primary care providers (PCPs), and nonpediatric GI specialists), and identified causes for variability and nonadherence. RESULTS: The antitissue transglutaminase antibody (tTG) IgA was ordered (n = 2504) most frequently by gastroenterologists (43%), endocrinologists (22%), and other (35%). Total IgA was ordered with tTG IgA for screening purposes in 81% of overall cases, but endocrinologists ordered it only 49% of the time. The tTG IgG was ordered infrequently (1.9%) compared with tTG IgA. Antideaminated gliadin peptide (DGP) IgA/IgG levels were also infrequently ordered (5.4%) compared with tTG IgA. The antiendomysial antibody was ordered sparingly (0.9%) compared with tTG IgA, but appropriately by providers with expertise in CD, similar to ordering for celiac genetics (0.8%). Of the celiac genetic tests, 15% were ordered in error. The positivity rate of the tTG IgA ordered by PCPs was 4.4%. CONCLUSIONS: The tTG IgA was appropriately ordered by all types of providers. Endocrinologists inconsistently ordered total IgA levels with screening labs. DGP IgA/IgG tests were not commonly ordered but were inappropriately ordered by one provider. The low number of ordered antiendomysial antibody and celiac genetic tests suggests under-utilization of the nonbiopsy approach. The positive yield of tTG IgA ordered by PCPs was higher compared with previous studies. Lippincott Williams & Wilkins, Inc. 2023-03-24 /pmc/articles/PMC10187855/ /pubmed/37200734 http://dx.doi.org/10.1097/PG9.0000000000000302 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Article
Chugh, Ankur
Lo, Stanley F.
Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience
title Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience
title_full Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience
title_fullStr Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience
title_full_unstemmed Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience
title_short Variability in Celiac Serology Testing by Provider Type: A Single-Center Experience
title_sort variability in celiac serology testing by provider type: a single-center experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187855/
https://www.ncbi.nlm.nih.gov/pubmed/37200734
http://dx.doi.org/10.1097/PG9.0000000000000302
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