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Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease that presents with neurologic manifestations such as stroke, psychiatric disturbances, migraine, and cognitive decline. We report a case of a previously well 27-year-old l...

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Autores principales: Zafar, Mansoor, Gajre, Meera, Balagopal, Aparna, Naqvi, Syed Ashhar, Khalesi, Darius S, Premathilaka, Rusiru, Islam, Ariful, Berliti, Stefano, Hovagim, Garabedyan, Hacikurt, Kadir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187981/
https://www.ncbi.nlm.nih.gov/pubmed/37205173
http://dx.doi.org/10.7759/cureus.39099
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author Zafar, Mansoor
Gajre, Meera
Balagopal, Aparna
Naqvi, Syed Ashhar
Khalesi, Darius S
Premathilaka, Rusiru
Islam, Ariful
Berliti, Stefano
Hovagim, Garabedyan
Hacikurt, Kadir
author_facet Zafar, Mansoor
Gajre, Meera
Balagopal, Aparna
Naqvi, Syed Ashhar
Khalesi, Darius S
Premathilaka, Rusiru
Islam, Ariful
Berliti, Stefano
Hovagim, Garabedyan
Hacikurt, Kadir
author_sort Zafar, Mansoor
collection PubMed
description Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease that presents with neurologic manifestations such as stroke, psychiatric disturbances, migraine, and cognitive decline. We report a case of a previously well 27-year-old lady presenting with new onset confusion four weeks postpartum. On examination, there was right-sided weakness and tremors. A thorough history revealed existing diagnoses of CADASIL in 1(st) and 2(nd)-degree relatives. The diagnosis in this patient was confirmed by MRI of the brain and genetic testing for NOTCH 3 mutation. The patient was admitted to the stroke ward, treated with a single antiplatelet agent for stroke, and supported by speech and language therapy. There was a significant symptomatic improvement in her speech at the time of discharge. The mainstay of treatment for CADASIL remains symptomatic at this stage. This case report shows that the first presentation of CADASIL can mimic postpartum psychiatric disorders in a puerperal woman.
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spelling pubmed-101879812023-05-17 Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis Zafar, Mansoor Gajre, Meera Balagopal, Aparna Naqvi, Syed Ashhar Khalesi, Darius S Premathilaka, Rusiru Islam, Ariful Berliti, Stefano Hovagim, Garabedyan Hacikurt, Kadir Cureus Genetics Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare inherited disease that presents with neurologic manifestations such as stroke, psychiatric disturbances, migraine, and cognitive decline. We report a case of a previously well 27-year-old lady presenting with new onset confusion four weeks postpartum. On examination, there was right-sided weakness and tremors. A thorough history revealed existing diagnoses of CADASIL in 1(st) and 2(nd)-degree relatives. The diagnosis in this patient was confirmed by MRI of the brain and genetic testing for NOTCH 3 mutation. The patient was admitted to the stroke ward, treated with a single antiplatelet agent for stroke, and supported by speech and language therapy. There was a significant symptomatic improvement in her speech at the time of discharge. The mainstay of treatment for CADASIL remains symptomatic at this stage. This case report shows that the first presentation of CADASIL can mimic postpartum psychiatric disorders in a puerperal woman. Cureus 2023-05-16 /pmc/articles/PMC10187981/ /pubmed/37205173 http://dx.doi.org/10.7759/cureus.39099 Text en Copyright © 2023, Zafar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Zafar, Mansoor
Gajre, Meera
Balagopal, Aparna
Naqvi, Syed Ashhar
Khalesi, Darius S
Premathilaka, Rusiru
Islam, Ariful
Berliti, Stefano
Hovagim, Garabedyan
Hacikurt, Kadir
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis
title Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis
title_full Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis
title_fullStr Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis
title_full_unstemmed Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis
title_short Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Presenting During the Postpartum Period as Postpartum Depression and Postpartum Psychosis
title_sort cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy presenting during the postpartum period as postpartum depression and postpartum psychosis
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10187981/
https://www.ncbi.nlm.nih.gov/pubmed/37205173
http://dx.doi.org/10.7759/cureus.39099
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