Cargando…

Physiological and Pathological Functions of TMEM30A: An Essential Subunit of P4-ATPase Phospholipid Flippases

Phospholipids are asymmetrically distributed across mammalian plasma membrane. The function of P4-ATPases is to maintain the abundance of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in the inner leaflet as lipid flippases. Transmembrane protein 30A (TMEM30A, also named CDC50A), as an e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jingyi, Zhao, Yue, Wang, Na
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188266/ https://www.ncbi.nlm.nih.gov/pubmed/37200892 http://dx.doi.org/10.1155/2023/4625567

Ejemplares similares

P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas
por: Andersen, Jens P., et al.
Publicado: (2016)

The phosphatidylserine flippase β-subunit Tmem30a is essential for normal insulin maturation and secretion
por: Yang, Yeming, et al.
Publicado: (2021)

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis
por: Liu, Wenjing, et al.
Publicado: (2021)

Proteomic Analysis and Functional Characterization of P4-ATPase Phospholipid Flippases from Murine Tissues
por: Wang, Jiao, et al.
Publicado: (2018)

P4 ATPases: Flippases in Health and Disease
por: van der Mark, Vincent A., et al.
Publicado: (2013)

Deletion of a flippase subunit Tmem30a in hematopoietic cells impairs mouse fetal liver erythropoiesis
por: Yang, Fan, et al.
Publicado: (2019)

P4-ATPases: lipid flippases in cell membranes
por: Lopez-Marques, Rosa L., et al.
Publicado: (2013)

Transport mechanism of P4 ATPase phosphatidylcholine flippases
por: Bai, Lin, et al.
Publicado: (2020)

Deletion of phosphatidylserine flippase β-subunit Tmem30a in satellite cells leads to delayed skeletal muscle regeneration
por: Sun, Kuan-Xiang, et al.
Publicado: (2021)

C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity
por: Chalat, Madhavan, et al.
Publicado: (2017)

Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane
por: Kishimoto, Takuma, et al.
Publicado: (2021)

Structures of a P4-ATPase lipid flippase in lipid bilayers
por: He, Yilin, et al.
Publicado: (2020)

Structural basis of the P4B ATPase lipid flippase activity
por: Bai, Lin, et al.
Publicado: (2021)

Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases
por: Sakuragi, Takaharu, et al.
Publicado: (2023)

A Putative Plant Aminophospholipid Flippase, the Arabidopsis P4 ATPase ALA1, Localizes to the Plasma Membrane following Association with a β-Subunit
por: López-Marqués, Rosa L., et al.
Publicado: (2012)

Phospholipid flippases and Sfk1p, a novel regulator of phospholipid asymmetry, contribute to low permeability of the plasma membrane
por: Mioka, Tetsuo, et al.
Publicado: (2018)

The phospholipid flippase ALA3 regulates pollen tube growth and guidance in Arabidopsis
por: Yang, Yang, et al.
Publicado: (2022)

Asymmetric distribution of phosphatidylserine is generated in the absence of phospholipid flippases in Saccharomyces cerevisiae
por: Mioka, Tetsuo, et al.
Publicado: (2014)

Inositol Depletion Restores Vesicle Transport in Yeast Phospholipid Flippase Mutants
por: Yamagami, Kanako, et al.
Publicado: (2015)

The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages
por: Gómez‐Mellado, Valentina E., et al.
Publicado: (2022)

The lipid head group is the key element for substrate recognition by the P4 ATPase ALA2: a phosphatidylserine flippase
por: Theorin, Lisa, et al.
Publicado: (2019)

Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance
por: Ernst, Christoph M., et al.
Publicado: (2018)

An optogenetic system to control membrane phospholipid asymmetry through flippase activation in budding yeast
por: Suzuki, Tomomi, et al.
Publicado: (2020)

A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission
por: Yang, Zhenke, et al.
Publicado: (2021)

Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4
por: van der Mark, Vincent A., et al.
Publicado: (2016)

Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases
por: Tomaszowski, Karl-Heinz, et al.
Publicado: (2017)

Cfs1p, a Novel Membrane Protein in the PQ-Loop Family, Is Involved in Phospholipid Flippase Functions in Yeast
por: Yamamoto, Takaharu, et al.
Publicado: (2016)

The Drosophila melanogaster Phospholipid Flippase dATP8B Is Required for Odorant Receptor Function
por: Liu, Yu-Chi, et al.
Publicado: (2014)

The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane
por: Tanaka, Yoshiki, et al.
Publicado: (2016)

Extracellular vesicle budding is inhibited by redundant regulators of TAT-5 flippase localization and phospholipid asymmetry
por: Beer, Katharina B., et al.
Publicado: (2018)

Phospholipid flipping involves a central cavity in P4 ATPases
por: Jensen, M. S., et al.
Publicado: (2017)

P-Type ATPase Apt1 of the Fungal Pathogen Cryptococcus neoformans Is a Lipid Flippase of Broad Substrate Specificity
por: Stanchev, Lyubomir Dimitrov, et al.
Publicado: (2021)

Human V-ATPase a-subunit isoforms bind specifically to distinct phosphoinositide phospholipids
por: Mitra, Connie, et al.
Publicado: (2023)

The ATPase activity of the phosphatidylethanolamine flippase TAT-5 inhibits extracellular vesicle budding from the plasma membrane
por: Pitts, Lauren R, et al.
Publicado: (2023)

Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans
por: Huang, Wei, et al.
Publicado: (2016)

Phospholipid flippase ATP11C is endocytosed and downregulated following Ca(2+)-mediated protein kinase C activation
por: Takatsu, Hiroyuki, et al.
Publicado: (2017)

Single-molecule analysis of phospholipid scrambling by TMEM16F
por: Watanabe, Rikiya, et al.
Publicado: (2018)

Phospholipid scrambling by a TMEM16 homolog of Arabidopsis thaliana
por: Boccaccio, Anna, et al.
Publicado: (2021)

PUB11-Dependent Ubiquitination of the Phospholipid Flippase ALA10 Modifies ALA10 Localization and Affects the Pool of Linolenic Phosphatidylcholine
por: Salvaing, Juliette, et al.
Publicado: (2020)

The Lipid-Modifying Multiple Peptide Resistance Factor Is an Oligomer Consisting of Distinct Interacting Synthase and Flippase Subunits
por: Ernst, Christoph M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_as8umi1vfqlv0vi8uqhco2a9ut