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Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer

Stauffer’s syndrome is a paraneoplastic syndrome that has historically been associated with renal cell carcinoma. It is defined by the anicteric elevation of liver enzymes in the absence of liver metastasis, and the reversibility of clinical and biochemical changes upon treatment of the primary path...

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Autores principales: Khanal, Sneha, Bhatt, Tanushree, Atogwe, Irhoboudu Dickson, Itare, Vikram, Shrestha, Elina, Sulh, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188316/
https://www.ncbi.nlm.nih.gov/pubmed/37200673
http://dx.doi.org/10.7759/cureus.37663
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author Khanal, Sneha
Bhatt, Tanushree
Atogwe, Irhoboudu Dickson
Itare, Vikram
Shrestha, Elina
Sulh, Muhammad
author_facet Khanal, Sneha
Bhatt, Tanushree
Atogwe, Irhoboudu Dickson
Itare, Vikram
Shrestha, Elina
Sulh, Muhammad
author_sort Khanal, Sneha
collection PubMed
description Stauffer’s syndrome is a paraneoplastic syndrome that has historically been associated with renal cell carcinoma. It is defined by the anicteric elevation of liver enzymes in the absence of liver metastasis, and the reversibility of clinical and biochemical changes upon treatment of the primary pathology. Here, we discuss the rare presentation of Stauffer’s syndrome in a patient with advanced metastatic prostate cancer. A 72-year-old male presented with generalized weakness, dizziness, weight loss, and icterus who was incidentally found to have a prostatic enlargement on physical examination. The laboratory investigations and radiographic imaging confirmed the diagnosis of metastatic prostatic cancer without any evidence of mechanical biliary obstruction as confirmed by biopsy and imaging. The cancer had metastasized to pelvic sidewalls, pelvic bones, ribs, urinary bladder, and local lymph nodes. Our case signifies that a high index of suspicion for underlying cancer should be maintained in patients presenting with cholestatic liver dysfunction, with or without jaundice, especially in the absence of a recognizable mechanical etiology of cholestasis. 
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spelling pubmed-101883162023-05-17 Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer Khanal, Sneha Bhatt, Tanushree Atogwe, Irhoboudu Dickson Itare, Vikram Shrestha, Elina Sulh, Muhammad Cureus Internal Medicine Stauffer’s syndrome is a paraneoplastic syndrome that has historically been associated with renal cell carcinoma. It is defined by the anicteric elevation of liver enzymes in the absence of liver metastasis, and the reversibility of clinical and biochemical changes upon treatment of the primary pathology. Here, we discuss the rare presentation of Stauffer’s syndrome in a patient with advanced metastatic prostate cancer. A 72-year-old male presented with generalized weakness, dizziness, weight loss, and icterus who was incidentally found to have a prostatic enlargement on physical examination. The laboratory investigations and radiographic imaging confirmed the diagnosis of metastatic prostatic cancer without any evidence of mechanical biliary obstruction as confirmed by biopsy and imaging. The cancer had metastasized to pelvic sidewalls, pelvic bones, ribs, urinary bladder, and local lymph nodes. Our case signifies that a high index of suspicion for underlying cancer should be maintained in patients presenting with cholestatic liver dysfunction, with or without jaundice, especially in the absence of a recognizable mechanical etiology of cholestasis.  Cureus 2023-04-16 /pmc/articles/PMC10188316/ /pubmed/37200673 http://dx.doi.org/10.7759/cureus.37663 Text en Copyright © 2023, Khanal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Khanal, Sneha
Bhatt, Tanushree
Atogwe, Irhoboudu Dickson
Itare, Vikram
Shrestha, Elina
Sulh, Muhammad
Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer
title Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer
title_full Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer
title_fullStr Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer
title_full_unstemmed Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer
title_short Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer
title_sort stauffer syndrome as the initial presentation of advanced metastatic prostate cancer
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188316/
https://www.ncbi.nlm.nih.gov/pubmed/37200673
http://dx.doi.org/10.7759/cureus.37663
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