Cargando…
Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer
Stauffer’s syndrome is a paraneoplastic syndrome that has historically been associated with renal cell carcinoma. It is defined by the anicteric elevation of liver enzymes in the absence of liver metastasis, and the reversibility of clinical and biochemical changes upon treatment of the primary path...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188316/ https://www.ncbi.nlm.nih.gov/pubmed/37200673 http://dx.doi.org/10.7759/cureus.37663 |
_version_ | 1785042886333562880 |
---|---|
author | Khanal, Sneha Bhatt, Tanushree Atogwe, Irhoboudu Dickson Itare, Vikram Shrestha, Elina Sulh, Muhammad |
author_facet | Khanal, Sneha Bhatt, Tanushree Atogwe, Irhoboudu Dickson Itare, Vikram Shrestha, Elina Sulh, Muhammad |
author_sort | Khanal, Sneha |
collection | PubMed |
description | Stauffer’s syndrome is a paraneoplastic syndrome that has historically been associated with renal cell carcinoma. It is defined by the anicteric elevation of liver enzymes in the absence of liver metastasis, and the reversibility of clinical and biochemical changes upon treatment of the primary pathology. Here, we discuss the rare presentation of Stauffer’s syndrome in a patient with advanced metastatic prostate cancer. A 72-year-old male presented with generalized weakness, dizziness, weight loss, and icterus who was incidentally found to have a prostatic enlargement on physical examination. The laboratory investigations and radiographic imaging confirmed the diagnosis of metastatic prostatic cancer without any evidence of mechanical biliary obstruction as confirmed by biopsy and imaging. The cancer had metastasized to pelvic sidewalls, pelvic bones, ribs, urinary bladder, and local lymph nodes. Our case signifies that a high index of suspicion for underlying cancer should be maintained in patients presenting with cholestatic liver dysfunction, with or without jaundice, especially in the absence of a recognizable mechanical etiology of cholestasis. |
format | Online Article Text |
id | pubmed-10188316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-101883162023-05-17 Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer Khanal, Sneha Bhatt, Tanushree Atogwe, Irhoboudu Dickson Itare, Vikram Shrestha, Elina Sulh, Muhammad Cureus Internal Medicine Stauffer’s syndrome is a paraneoplastic syndrome that has historically been associated with renal cell carcinoma. It is defined by the anicteric elevation of liver enzymes in the absence of liver metastasis, and the reversibility of clinical and biochemical changes upon treatment of the primary pathology. Here, we discuss the rare presentation of Stauffer’s syndrome in a patient with advanced metastatic prostate cancer. A 72-year-old male presented with generalized weakness, dizziness, weight loss, and icterus who was incidentally found to have a prostatic enlargement on physical examination. The laboratory investigations and radiographic imaging confirmed the diagnosis of metastatic prostatic cancer without any evidence of mechanical biliary obstruction as confirmed by biopsy and imaging. The cancer had metastasized to pelvic sidewalls, pelvic bones, ribs, urinary bladder, and local lymph nodes. Our case signifies that a high index of suspicion for underlying cancer should be maintained in patients presenting with cholestatic liver dysfunction, with or without jaundice, especially in the absence of a recognizable mechanical etiology of cholestasis. Cureus 2023-04-16 /pmc/articles/PMC10188316/ /pubmed/37200673 http://dx.doi.org/10.7759/cureus.37663 Text en Copyright © 2023, Khanal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Khanal, Sneha Bhatt, Tanushree Atogwe, Irhoboudu Dickson Itare, Vikram Shrestha, Elina Sulh, Muhammad Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer |
title | Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer |
title_full | Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer |
title_fullStr | Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer |
title_full_unstemmed | Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer |
title_short | Stauffer Syndrome as the Initial Presentation of Advanced Metastatic Prostate Cancer |
title_sort | stauffer syndrome as the initial presentation of advanced metastatic prostate cancer |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188316/ https://www.ncbi.nlm.nih.gov/pubmed/37200673 http://dx.doi.org/10.7759/cureus.37663 |
work_keys_str_mv | AT khanalsneha stauffersyndromeastheinitialpresentationofadvancedmetastaticprostatecancer AT bhatttanushree stauffersyndromeastheinitialpresentationofadvancedmetastaticprostatecancer AT atogweirhoboududickson stauffersyndromeastheinitialpresentationofadvancedmetastaticprostatecancer AT itarevikram stauffersyndromeastheinitialpresentationofadvancedmetastaticprostatecancer AT shresthaelina stauffersyndromeastheinitialpresentationofadvancedmetastaticprostatecancer AT sulhmuhammad stauffersyndromeastheinitialpresentationofadvancedmetastaticprostatecancer |