Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base editors (ABEs). To develop a CBE that retains the small size, low off-target activity and high on-target activity of current ABEs, we evolved the hig...

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Detalles Bibliográficos
Autores principales: Neugebauer, Monica E., Hsu, Alvin, Arbab, Mandana, Krasnow, Nicholas A., McElroy, Amber N., Pandey, Smriti, Doman, Jordan L., Huang, Tony P., Raguram, Aditya, Banskota, Samagya, Newby, Gregory A., Tolar, Jakub, Osborn, Mark J., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188366/
https://www.ncbi.nlm.nih.gov/pubmed/36357719
http://dx.doi.org/10.1038/s41587-022-01533-6

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