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Improved cytosine base editors generated from TadA variants

Cytosine base editors (CBEs) enable programmable genomic C·G-to-T·A transition mutations and typically comprise a modified CRISPR–Cas enzyme, a naturally occurring cytidine deaminase, and an inhibitor of uracil repair. Previous studies have shown that CBEs utilizing naturally occurring cytidine deam...

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Detalles Bibliográficos
Autores principales:	Lam, Dieter K., Feliciano, Patricia R., Arif, Amena, Bohnuud, Tanggis, Fernandez, Thomas P., Gehrke, Jason M., Grayson, Phil, Lee, Kin D., Ortega, Manuel A., Sawyer, Courtney, Schwaegerle, Noah D., Peraro, Leila, Young, Lauren, Lee, Seung-Joo, Ciaramella, Giuseppe, Gaudelli, Nicole M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188367/ https://www.ncbi.nlm.nih.gov/pubmed/36624149 http://dx.doi.org/10.1038/s41587-022-01611-9

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