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Non-visual hallucinations in Parkinson’s disease: a systematic review

BACKGROUND: Non-visual hallucinations in Parkinson’s disease (PD) can be prevalent and distressing. Most existing research has however, focused on visual hallucinations as well as related risk factors. The current study thus conducted a systematic review to collate existing evidence on non-visual ha...

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Autores principales: Toh, Wei Lin, Yolland, Caitlin, Gurvich, Caroline, Barnes, James, Rossell, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188425/
https://www.ncbi.nlm.nih.gov/pubmed/36702960
http://dx.doi.org/10.1007/s00415-022-11545-6
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author Toh, Wei Lin
Yolland, Caitlin
Gurvich, Caroline
Barnes, James
Rossell, Susan L.
author_facet Toh, Wei Lin
Yolland, Caitlin
Gurvich, Caroline
Barnes, James
Rossell, Susan L.
author_sort Toh, Wei Lin
collection PubMed
description BACKGROUND: Non-visual hallucinations in Parkinson’s disease (PD) can be prevalent and distressing. Most existing research has however, focused on visual hallucinations as well as related risk factors. The current study thus conducted a systematic review to collate existing evidence on non-visual hallucinations in PD, focusing on their prevalence, phenomenology, and clinical-cognitive correlates. METHODS: Ninety-one relevant studies were included from a systematic search across PsycINFO APA, PubMed, and Web of Science, for peer-reviewed publications in the English language, from 1970 to the present. These comprised a mix of case (30 studies; n = 56) and group design (62 studies; n = 7346) studies, divided into three somewhat overlapping collections to address our three research foci. RESULTS: Prevalence estimates for hallucinations were: auditory 1.5–72.0%, olfactory 1.6–21.0%, somatic-tactile 0.4–22.5%, gustatory 1.0–15.0%, and sensed presence 0.9–73.3%. Phenomenological inquiries revealed descriptions of vivid, consuming events replete with elaborate detail, adversely affecting PD patients in different ways. Overt experiences of multisensory hallucinations were also highly variable (0.4–80%) but exceedingly common, reported by almost half of the 45 included prevalence studies. There was some evidence for modality-specific hallucination predictors, but this was largely tentative, pending robust replication. CONCLUSIONS: Marked prevalence figures coupled with phenomenological descriptions implicating distress denote that non-visual and multisensory hallucinations in PD are of clinical significance. More direct research and clinical attention need to be devoted to the study and management of such hallucinatory experiences. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11545-6.
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spelling pubmed-101884252023-05-18 Non-visual hallucinations in Parkinson’s disease: a systematic review Toh, Wei Lin Yolland, Caitlin Gurvich, Caroline Barnes, James Rossell, Susan L. J Neurol Review BACKGROUND: Non-visual hallucinations in Parkinson’s disease (PD) can be prevalent and distressing. Most existing research has however, focused on visual hallucinations as well as related risk factors. The current study thus conducted a systematic review to collate existing evidence on non-visual hallucinations in PD, focusing on their prevalence, phenomenology, and clinical-cognitive correlates. METHODS: Ninety-one relevant studies were included from a systematic search across PsycINFO APA, PubMed, and Web of Science, for peer-reviewed publications in the English language, from 1970 to the present. These comprised a mix of case (30 studies; n = 56) and group design (62 studies; n = 7346) studies, divided into three somewhat overlapping collections to address our three research foci. RESULTS: Prevalence estimates for hallucinations were: auditory 1.5–72.0%, olfactory 1.6–21.0%, somatic-tactile 0.4–22.5%, gustatory 1.0–15.0%, and sensed presence 0.9–73.3%. Phenomenological inquiries revealed descriptions of vivid, consuming events replete with elaborate detail, adversely affecting PD patients in different ways. Overt experiences of multisensory hallucinations were also highly variable (0.4–80%) but exceedingly common, reported by almost half of the 45 included prevalence studies. There was some evidence for modality-specific hallucination predictors, but this was largely tentative, pending robust replication. CONCLUSIONS: Marked prevalence figures coupled with phenomenological descriptions implicating distress denote that non-visual and multisensory hallucinations in PD are of clinical significance. More direct research and clinical attention need to be devoted to the study and management of such hallucinatory experiences. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11545-6. Springer Berlin Heidelberg 2023-01-27 2023 /pmc/articles/PMC10188425/ /pubmed/36702960 http://dx.doi.org/10.1007/s00415-022-11545-6 Text en © The Author(s) 2023, corrected publication 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Toh, Wei Lin
Yolland, Caitlin
Gurvich, Caroline
Barnes, James
Rossell, Susan L.
Non-visual hallucinations in Parkinson’s disease: a systematic review
title Non-visual hallucinations in Parkinson’s disease: a systematic review
title_full Non-visual hallucinations in Parkinson’s disease: a systematic review
title_fullStr Non-visual hallucinations in Parkinson’s disease: a systematic review
title_full_unstemmed Non-visual hallucinations in Parkinson’s disease: a systematic review
title_short Non-visual hallucinations in Parkinson’s disease: a systematic review
title_sort non-visual hallucinations in parkinson’s disease: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188425/
https://www.ncbi.nlm.nih.gov/pubmed/36702960
http://dx.doi.org/10.1007/s00415-022-11545-6
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