The accuracy of haemoglobin A(2) measurements in the presence and absence of haemoglobin S

The quantification of haemoglobin A(2) by high‐performance liquid chromatography (HPLC) was compared with quantification by capillary electrophoresis for control subjects and patients with sickle cell trait or sickle cell anaemia. Significant differences were found, with estimated values being highe...

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Detalles Bibliográficos
Autores principales: Myburgh, Jane K., Szydlo, Richard M., Bain, Barbara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188449/
https://www.ncbi.nlm.nih.gov/pubmed/37206262
http://dx.doi.org/10.1002/jha2.691
Descripción
Sumario:The quantification of haemoglobin A(2) by high‐performance liquid chromatography (HPLC) was compared with quantification by capillary electrophoresis for control subjects and patients with sickle cell trait or sickle cell anaemia. Significant differences were found, with estimated values being higher by HPLC for control subjects and higher by capillary electrophoresis for sickle cell trait and sickle cell anaemia patients. There is an ongoing need for improved standardisation and alignment of methods.

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