Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma

Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50‐year‐old man with severe systemic osteosclerosis...

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Autores principales: Ozaki, Shuji, Iima, Tsutomu, Sekimoto, Etsuko, Shibata, Hironobu, Shigekiyo, Toshio, Higuchi, Yukio, Hirose, Takanori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188472/
https://www.ncbi.nlm.nih.gov/pubmed/37206285
http://dx.doi.org/10.1002/jha2.652
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author Ozaki, Shuji
Iima, Tsutomu
Sekimoto, Etsuko
Shibata, Hironobu
Shigekiyo, Toshio
Higuchi, Yukio
Hirose, Takanori
author_facet Ozaki, Shuji
Iima, Tsutomu
Sekimoto, Etsuko
Shibata, Hironobu
Shigekiyo, Toshio
Higuchi, Yukio
Hirose, Takanori
author_sort Ozaki, Shuji
collection PubMed
description Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50‐year‐old man with severe systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.
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spelling pubmed-101884722023-05-18 Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma Ozaki, Shuji Iima, Tsutomu Sekimoto, Etsuko Shibata, Hironobu Shigekiyo, Toshio Higuchi, Yukio Hirose, Takanori EJHaem Case Reports Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50‐year‐old man with severe systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies. John Wiley and Sons Inc. 2023-02-05 /pmc/articles/PMC10188472/ /pubmed/37206285 http://dx.doi.org/10.1002/jha2.652 Text en © 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Ozaki, Shuji
Iima, Tsutomu
Sekimoto, Etsuko
Shibata, Hironobu
Shigekiyo, Toshio
Higuchi, Yukio
Hirose, Takanori
Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma
title Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma
title_full Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma
title_fullStr Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma
title_full_unstemmed Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma
title_short Systemic osteosclerosis associated with primary bone marrow B‐cell lymphoma
title_sort systemic osteosclerosis associated with primary bone marrow b‐cell lymphoma
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188472/
https://www.ncbi.nlm.nih.gov/pubmed/37206285
http://dx.doi.org/10.1002/jha2.652
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