HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1

Epithelial-mesenchymal transition (EMT) is associated with the invasive and metastatic phenotypes in colorectal cancer (CRC). However, the mechanisms underlying EMT in CRC are not completely understood. In this study, we find that HUNK inhibits EMT and metastasis of CRC cells via its substrate GEF-H...

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Detalles Bibliográficos
Autores principales: Han, Xiaoqi, Jiang, Siyuan, Gu, Yinmin, Ding, Lihua, Zhao, Enhao, Cao, Dongxing, Wang, Xiaodong, Wen, Ya, Pan, Yongbo, Yan, Xin, Duan, Liqiang, Sun, Minxuan, Zhou, Tao, Liu, Yajuan, Hu, Hongbo, Ye, Qinong, Gao, Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188538/
https://www.ncbi.nlm.nih.gov/pubmed/37193711
http://dx.doi.org/10.1038/s41419-023-05849-2

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