Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM

The eukaryotic chaperonin TRiC/CCT assists the folding of about 10% of cytosolic proteins through an ATP-driven conformational cycle, and the essential cytoskeleton protein tubulin is the obligate substrate of TRiC. Here, we present an ensemble of cryo-EM structures of endogenous human TRiC througho...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Caixuan, Jin, Mingliang, Wang, Shutian, Han, Wenyu, Zhao, Qiaoyu, Wang, Yifan, Xu, Cong, Diao, Lei, Yin, Yue, Peng, Chao, Bao, Lan, Wang, Yanxing, Cong, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188570/
https://www.ncbi.nlm.nih.gov/pubmed/37193829
http://dx.doi.org/10.1038/s42003-023-04915-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188570/
https://www.ncbi.nlm.nih.gov/pubmed/37193829
http://dx.doi.org/10.1038/s42003-023-04915-x

Ejemplares similares