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Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates
Toxoplasma gondii (T. gondii) is a nucleated intracellular parasitic protozoan with a broad host selectivity. It causes toxoplasmosis in immunocompromised or immunodeficient patients. The currently available treatments for toxoplasmosis have significant side effects as well as certain limitations, a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188992/ https://www.ncbi.nlm.nih.gov/pubmed/37205912 http://dx.doi.org/10.3389/fphar.2023.1178070 |
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author | Yang, Dongqian Liu, Xiaohua Li, Jing Xie, Jing Jiang, Liping |
author_facet | Yang, Dongqian Liu, Xiaohua Li, Jing Xie, Jing Jiang, Liping |
author_sort | Yang, Dongqian |
collection | PubMed |
description | Toxoplasma gondii (T. gondii) is a nucleated intracellular parasitic protozoan with a broad host selectivity. It causes toxoplasmosis in immunocompromised or immunodeficient patients. The currently available treatments for toxoplasmosis have significant side effects as well as certain limitations, and the development of vaccines remains to be explored. Animal venoms are considered to be an important source of novel antimicrobial agents. Some peptides from animal venoms have amphipathic alpha-helix structures. They inhibit the growth of pathogens by targeting membranes to produce lethal pores and cause membrane rupture. Venom molecules generally possess immunomodulatory properties and play key roles in the suppression of pathogenic organisms. Here, we summarized literatures of the last 15 years on the interaction of animal venom peptides with T. gondii and attempt to explore the mechanisms of their interaction with parasites that involve membrane and organelle damage, immune response regulation and ion homeostasis. Finally, we analyzed some limitations of venom peptides for drug therapy and some insights into their development in future studies. It is hoped that more research will be stimulated to turn attention to the medical value of animal venoms in toxoplasmosis. |
format | Online Article Text |
id | pubmed-10188992 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101889922023-05-18 Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates Yang, Dongqian Liu, Xiaohua Li, Jing Xie, Jing Jiang, Liping Front Pharmacol Pharmacology Toxoplasma gondii (T. gondii) is a nucleated intracellular parasitic protozoan with a broad host selectivity. It causes toxoplasmosis in immunocompromised or immunodeficient patients. The currently available treatments for toxoplasmosis have significant side effects as well as certain limitations, and the development of vaccines remains to be explored. Animal venoms are considered to be an important source of novel antimicrobial agents. Some peptides from animal venoms have amphipathic alpha-helix structures. They inhibit the growth of pathogens by targeting membranes to produce lethal pores and cause membrane rupture. Venom molecules generally possess immunomodulatory properties and play key roles in the suppression of pathogenic organisms. Here, we summarized literatures of the last 15 years on the interaction of animal venom peptides with T. gondii and attempt to explore the mechanisms of their interaction with parasites that involve membrane and organelle damage, immune response regulation and ion homeostasis. Finally, we analyzed some limitations of venom peptides for drug therapy and some insights into their development in future studies. It is hoped that more research will be stimulated to turn attention to the medical value of animal venoms in toxoplasmosis. Frontiers Media S.A. 2023-05-03 /pmc/articles/PMC10188992/ /pubmed/37205912 http://dx.doi.org/10.3389/fphar.2023.1178070 Text en Copyright © 2023 Yang, Liu, Li, Xie and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Yang, Dongqian Liu, Xiaohua Li, Jing Xie, Jing Jiang, Liping Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates |
title | Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates |
title_full | Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates |
title_fullStr | Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates |
title_full_unstemmed | Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates |
title_short | Animal venoms: a novel source of anti-Toxoplasma gondii drug candidates |
title_sort | animal venoms: a novel source of anti-toxoplasma gondii drug candidates |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10188992/ https://www.ncbi.nlm.nih.gov/pubmed/37205912 http://dx.doi.org/10.3389/fphar.2023.1178070 |
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