How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation

In recent years, with the gradual advancement of haploidentical transplantation technology, the availability of donors has increased significantly, along with the widespread use of reduced-intensity conditioning and the improvement of nursing techniques, giving more elderly acute myeloid leukemia (A...

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Autores principales: Jiang, Shan, Yan, Han, Lu, Xuan, Wei, Ruowen, Chen, Haoran, Zhang, Ao, Shi, Wei, Xia, Linghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189056/
https://www.ncbi.nlm.nih.gov/pubmed/37207218
http://dx.doi.org/10.3389/fimmu.2023.1102966
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author Jiang, Shan
Yan, Han
Lu, Xuan
Wei, Ruowen
Chen, Haoran
Zhang, Ao
Shi, Wei
Xia, Linghui
author_facet Jiang, Shan
Yan, Han
Lu, Xuan
Wei, Ruowen
Chen, Haoran
Zhang, Ao
Shi, Wei
Xia, Linghui
author_sort Jiang, Shan
collection PubMed
description In recent years, with the gradual advancement of haploidentical transplantation technology, the availability of donors has increased significantly, along with the widespread use of reduced-intensity conditioning and the improvement of nursing techniques, giving more elderly acute myeloid leukemia (AML) patients the chance to receive allogeneic hematopoietic stem cell transplantation. We have summarized the classic and recently proposed pre-transplant assessment methods and assessed the various sources of donors, conditioning regimens, and post-transplant complication management based on the outcomes of large-scale clinical studies for elderly AML patients.
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spelling pubmed-101890562023-05-18 How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation Jiang, Shan Yan, Han Lu, Xuan Wei, Ruowen Chen, Haoran Zhang, Ao Shi, Wei Xia, Linghui Front Immunol Immunology In recent years, with the gradual advancement of haploidentical transplantation technology, the availability of donors has increased significantly, along with the widespread use of reduced-intensity conditioning and the improvement of nursing techniques, giving more elderly acute myeloid leukemia (AML) patients the chance to receive allogeneic hematopoietic stem cell transplantation. We have summarized the classic and recently proposed pre-transplant assessment methods and assessed the various sources of donors, conditioning regimens, and post-transplant complication management based on the outcomes of large-scale clinical studies for elderly AML patients. Frontiers Media S.A. 2023-05-03 /pmc/articles/PMC10189056/ /pubmed/37207218 http://dx.doi.org/10.3389/fimmu.2023.1102966 Text en Copyright © 2023 Jiang, Yan, Lu, Wei, Chen, Zhang, Shi and Xia https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Jiang, Shan
Yan, Han
Lu, Xuan
Wei, Ruowen
Chen, Haoran
Zhang, Ao
Shi, Wei
Xia, Linghui
How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
title How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
title_full How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
title_fullStr How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
title_full_unstemmed How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
title_short How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
title_sort how to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189056/
https://www.ncbi.nlm.nih.gov/pubmed/37207218
http://dx.doi.org/10.3389/fimmu.2023.1102966
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