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The KEAP1-NRF2 pathway: Targets for therapy and role in cancer
The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, motivating research to elucidate the intricacies of...
Autores principales: | Adinolfi, Simone, Patinen, Tommi, Jawahar Deen, Ashik, Pitkänen, Sini, Härkönen, Jouni, Kansanen, Emilia, Küblbeck, Jenni, Levonen, Anna-Liisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189287/ https://www.ncbi.nlm.nih.gov/pubmed/37146513 http://dx.doi.org/10.1016/j.redox.2023.102726 |
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