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Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic infections severely limits the efficacy of antimicrobial therapies, as it leads to intrinsic tolerance, involving ph...

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Autores principales: Fernández-Billón, María, Llambías-Cabot, Aina E., Jordana-Lluch, Elena, Oliver, Antonio, Macià, María D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189392/
https://www.ncbi.nlm.nih.gov/pubmed/37205903
http://dx.doi.org/10.1016/j.bioflm.2023.100129
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author Fernández-Billón, María
Llambías-Cabot, Aina E.
Jordana-Lluch, Elena
Oliver, Antonio
Macià, María D.
author_facet Fernández-Billón, María
Llambías-Cabot, Aina E.
Jordana-Lluch, Elena
Oliver, Antonio
Macià, María D.
author_sort Fernández-Billón, María
collection PubMed
description Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic infections severely limits the efficacy of antimicrobial therapies, as it leads to intrinsic tolerance, involving physical and physiological factors in addition to biofilm-specific genes that can confer a transient protection against antibiotics promoting the development of resistance. Indeed, a striking feature of this pathogen is the extraordinary capacity to develop resistance to nearly all available antibiotics through the selection of chromosomal mutations, evidenced by its outstanding and versatile mutational resistome. This threat is dramatically amplified in chronic infections, driven by the frequent emergence of mutator variants with enhanced spontaneous mutation rates. Thus, this mini review is focused on describing the complex interplay of antibiotic resistance mechanisms in P. aeruginosa biofilms, to provide potentially useful information for the design of effective therapeutic strategies.
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spelling pubmed-101893922023-05-18 Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms Fernández-Billón, María Llambías-Cabot, Aina E. Jordana-Lluch, Elena Oliver, Antonio Macià, María D. Biofilm Article Pseudomonas aeruginosa is a major cause of life-threatening acute infections and life-long lasting chronic infections. The characteristic biofilm mode of life in P. aeruginosa chronic infections severely limits the efficacy of antimicrobial therapies, as it leads to intrinsic tolerance, involving physical and physiological factors in addition to biofilm-specific genes that can confer a transient protection against antibiotics promoting the development of resistance. Indeed, a striking feature of this pathogen is the extraordinary capacity to develop resistance to nearly all available antibiotics through the selection of chromosomal mutations, evidenced by its outstanding and versatile mutational resistome. This threat is dramatically amplified in chronic infections, driven by the frequent emergence of mutator variants with enhanced spontaneous mutation rates. Thus, this mini review is focused on describing the complex interplay of antibiotic resistance mechanisms in P. aeruginosa biofilms, to provide potentially useful information for the design of effective therapeutic strategies. Elsevier 2023-05-02 /pmc/articles/PMC10189392/ /pubmed/37205903 http://dx.doi.org/10.1016/j.bioflm.2023.100129 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Fernández-Billón, María
Llambías-Cabot, Aina E.
Jordana-Lluch, Elena
Oliver, Antonio
Macià, María D.
Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms
title Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms
title_full Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms
title_fullStr Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms
title_full_unstemmed Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms
title_short Mechanisms of antibiotic resistance in Pseudomonas aeruginosa biofilms
title_sort mechanisms of antibiotic resistance in pseudomonas aeruginosa biofilms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189392/
https://www.ncbi.nlm.nih.gov/pubmed/37205903
http://dx.doi.org/10.1016/j.bioflm.2023.100129
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