Thrombin-mediated activation of PAR1 enhances doxorubicin-induced cardiac injury in mice

The chemotherapeutic drug doxorubicin is cardiotoxic and can cause irreversible heart failure. In addition to being cardiotoxic, doxorubicin also induces the activation of coagulation. We determined the effect of thrombin-mediated activation of protease-activated receptor 1 (PAR1) on doxorubicin-ind...

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Detalles Bibliográficos
Autores principales: Grover, Steven P., Bharathi, Vanthana, Posma, Jens J., Griffin, John H., Palumbo, Joseph S., Mackman, Nigel, Antoniak, Silvio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189413/
https://www.ncbi.nlm.nih.gov/pubmed/36477178
http://dx.doi.org/10.1182/bloodadvances.2022008637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189413/
https://www.ncbi.nlm.nih.gov/pubmed/36477178
http://dx.doi.org/10.1182/bloodadvances.2022008637

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