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The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications

Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate has not improved significantly in the past 30 years, which brings a heavy burden to patients and society. The high heterogeneity of osteosarcoma leads to the lack of specific targets and poor therapeutic ef...

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Autores principales: Zeng, Jin, Peng, Yi, Wang, Dong, Ayesha, Khan, Chen, Shijie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189553/
https://www.ncbi.nlm.nih.gov/pubmed/37206921
http://dx.doi.org/10.3389/fcell.2023.1123065
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author Zeng, Jin
Peng, Yi
Wang, Dong
Ayesha, Khan
Chen, Shijie
author_facet Zeng, Jin
Peng, Yi
Wang, Dong
Ayesha, Khan
Chen, Shijie
author_sort Zeng, Jin
collection PubMed
description Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate has not improved significantly in the past 30 years, which brings a heavy burden to patients and society. The high heterogeneity of osteosarcoma leads to the lack of specific targets and poor therapeutic effect. Tumor microenvironment is the focus of current research, and osteosarcoma is closely related to bone microenvironment. Many soluble factors and extracellular matrix secreted by many cells in the bone microenvironment have been shown to affect the occurrence, proliferation, invasion and metastasis of osteosarcoma through a variety of signaling pathways. Therefore, targeting other cells in the bone microenvironment may improve the prognosis of osteosarcoma. The mechanism by which osteosarcoma interacts with other cells in the bone microenvironment has been extensively investigated, but currently developed drugs targeting the bone microenvironment have poor efficacy. Therefore, we review the regulatory effects of major cells and physical and chemical properties in the bone microenvironment on osteosarcoma, focusing on their complex interactions, potential therapeutic strategies and clinical applications, to deepen our understanding of osteosarcoma and the bone microenvironment and provide reference for future treatment. Targeting other cells in the bone microenvironment may provide potential targets for the development of clinical drugs for osteosarcoma and may improve the prognosis of osteosarcoma.
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spelling pubmed-101895532023-05-18 The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications Zeng, Jin Peng, Yi Wang, Dong Ayesha, Khan Chen, Shijie Front Cell Dev Biol Cell and Developmental Biology Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate has not improved significantly in the past 30 years, which brings a heavy burden to patients and society. The high heterogeneity of osteosarcoma leads to the lack of specific targets and poor therapeutic effect. Tumor microenvironment is the focus of current research, and osteosarcoma is closely related to bone microenvironment. Many soluble factors and extracellular matrix secreted by many cells in the bone microenvironment have been shown to affect the occurrence, proliferation, invasion and metastasis of osteosarcoma through a variety of signaling pathways. Therefore, targeting other cells in the bone microenvironment may improve the prognosis of osteosarcoma. The mechanism by which osteosarcoma interacts with other cells in the bone microenvironment has been extensively investigated, but currently developed drugs targeting the bone microenvironment have poor efficacy. Therefore, we review the regulatory effects of major cells and physical and chemical properties in the bone microenvironment on osteosarcoma, focusing on their complex interactions, potential therapeutic strategies and clinical applications, to deepen our understanding of osteosarcoma and the bone microenvironment and provide reference for future treatment. Targeting other cells in the bone microenvironment may provide potential targets for the development of clinical drugs for osteosarcoma and may improve the prognosis of osteosarcoma. Frontiers Media S.A. 2023-05-03 /pmc/articles/PMC10189553/ /pubmed/37206921 http://dx.doi.org/10.3389/fcell.2023.1123065 Text en Copyright © 2023 Zeng, Peng, Wang, Ayesha and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zeng, Jin
Peng, Yi
Wang, Dong
Ayesha, Khan
Chen, Shijie
The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
title The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
title_full The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
title_fullStr The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
title_full_unstemmed The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
title_short The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications
title_sort interaction between osteosarcoma and other cells in the bone microenvironment: from mechanism to clinical applications
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189553/
https://www.ncbi.nlm.nih.gov/pubmed/37206921
http://dx.doi.org/10.3389/fcell.2023.1123065
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