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An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma

Background ABO blood group types are hereditary factors that have been shown to affect the blood levels of many antigens and proteins. Some blood groups have surprisingly been shown to be associated with some specific diseases, probably due to yet unexplained altering effects on the immune system or...

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Autores principales: Lal, Teena, Sadhasivam, Muthukumar, K, Sunitha Priya A, J, Ajeet Arulkumar S, R, Padmavathi, Khaleeluddin, Kouser Banu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189660/
https://www.ncbi.nlm.nih.gov/pubmed/37206491
http://dx.doi.org/10.7759/cureus.37675
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author Lal, Teena
Sadhasivam, Muthukumar
K, Sunitha Priya A
J, Ajeet Arulkumar S
R, Padmavathi
Khaleeluddin, Kouser Banu
author_facet Lal, Teena
Sadhasivam, Muthukumar
K, Sunitha Priya A
J, Ajeet Arulkumar S
R, Padmavathi
Khaleeluddin, Kouser Banu
author_sort Lal, Teena
collection PubMed
description Background ABO blood group types are hereditary factors that have been shown to affect the blood levels of many antigens and proteins. Some blood groups have surprisingly been shown to be associated with some specific diseases, probably due to yet unexplained altering effects on the immune system or on the levels of other system-specific proteins. Studies conducted previously attempting to relate bronchial asthma and blood groups have had variable results and such studies on a large scale have not been ventured in India. Hence, the significance of the current study, which aims to search for an increased occurrence of bronchial asthma in any one of the ABO blood group phenotypes and additionally in Rh blood groups. Objective The objective of this study was to analyze the possible association of the ABO and Rh blood group types with bronchial asthma.  Methods This is an observational study with 475 bronchial asthma patients, and 2052 non-asthmatic individuals belonging to the same geographical zone. After obtaining informed consent, ABO and Rh Blood group testing was done on the study subjects using the hemagglutination method. Chi-squared tests were employed for the comparison of proportions. Statistical significance was agreed upon for an error of 5%. Results The O blood group was predominant in both cases (46.9 %) and controls (36.1%). A chi-square analysis revealed a statistically significant higher percentage of O blood group in patients (χ2: 24.537; degrees of freedom (DF): 3; p-value = <0.01). The cases had more Rh -ve individuals (12%) than controls (8%), which too was statistically significant (χ2: 6.711; degrees of freedom (DF): 1; p-value = 0.01). Conclusion The present study shows a positive association between the O blood group and the Rh-negative blood group with bronchial asthma.
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spelling pubmed-101896602023-05-18 An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma Lal, Teena Sadhasivam, Muthukumar K, Sunitha Priya A J, Ajeet Arulkumar S R, Padmavathi Khaleeluddin, Kouser Banu Cureus Internal Medicine Background ABO blood group types are hereditary factors that have been shown to affect the blood levels of many antigens and proteins. Some blood groups have surprisingly been shown to be associated with some specific diseases, probably due to yet unexplained altering effects on the immune system or on the levels of other system-specific proteins. Studies conducted previously attempting to relate bronchial asthma and blood groups have had variable results and such studies on a large scale have not been ventured in India. Hence, the significance of the current study, which aims to search for an increased occurrence of bronchial asthma in any one of the ABO blood group phenotypes and additionally in Rh blood groups. Objective The objective of this study was to analyze the possible association of the ABO and Rh blood group types with bronchial asthma.  Methods This is an observational study with 475 bronchial asthma patients, and 2052 non-asthmatic individuals belonging to the same geographical zone. After obtaining informed consent, ABO and Rh Blood group testing was done on the study subjects using the hemagglutination method. Chi-squared tests were employed for the comparison of proportions. Statistical significance was agreed upon for an error of 5%. Results The O blood group was predominant in both cases (46.9 %) and controls (36.1%). A chi-square analysis revealed a statistically significant higher percentage of O blood group in patients (χ2: 24.537; degrees of freedom (DF): 3; p-value = <0.01). The cases had more Rh -ve individuals (12%) than controls (8%), which too was statistically significant (χ2: 6.711; degrees of freedom (DF): 1; p-value = 0.01). Conclusion The present study shows a positive association between the O blood group and the Rh-negative blood group with bronchial asthma. Cureus 2023-04-17 /pmc/articles/PMC10189660/ /pubmed/37206491 http://dx.doi.org/10.7759/cureus.37675 Text en Copyright © 2023, Lal et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Lal, Teena
Sadhasivam, Muthukumar
K, Sunitha Priya A
J, Ajeet Arulkumar S
R, Padmavathi
Khaleeluddin, Kouser Banu
An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma
title An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma
title_full An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma
title_fullStr An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma
title_full_unstemmed An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma
title_short An Observational Study to Analyse the Association of the ABO and Rh Blood Group Systems With Bronchial Asthma
title_sort observational study to analyse the association of the abo and rh blood group systems with bronchial asthma
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189660/
https://www.ncbi.nlm.nih.gov/pubmed/37206491
http://dx.doi.org/10.7759/cureus.37675
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