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SETDB1 induces lenalidomide resistance in multiple myeloma cells via epithelial‑mesenchymal transition and PI3K/AKT pathway activation

SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) is a histone H3K9 methyltransferase that stimulates cell proliferation by methylating AKT, which contributes to drug resistance in multiple myeloma (MM). Lenalidomide is an immunomodulatory agent widely used in the treatment of MM. Ho...

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Detalles Bibliográficos
Autores principales:	Qian, Xiaoli, Yang, Yang, Deng, Yingfen, Liu, Yali, Zhou, Yuwen, Han, Fang, Xu, Yue, Yuan, Hongjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189757/ https://www.ncbi.nlm.nih.gov/pubmed/37206551 http://dx.doi.org/10.3892/etm.2023.11973

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