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Computable structured aptamer for targeted treatment of ovarian cancer

Nucleolin protein expression is higher on the ovarian cancer cell surface. AS1411, a DNA aptamer, can bind with nucleolin protein specifically. In this study, we developed HA and ST DNA tiles to assemble six AS1411 aptamers to deliver doxorubicin. In addition, to superior serum stability and drug lo...

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Detalles Bibliográficos
Autores principales:	Ruan, Luoshan, Han, Liting, Li, Xin, Chen, Xin, Sun, Gege, Wang, Xinyu, Luo, Yan, Gu, Chuanqi, Shi, Xiaolong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189780/ https://www.ncbi.nlm.nih.gov/pubmed/37206583 http://dx.doi.org/10.3389/fgene.2023.1170260

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