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Fertility preservation in pediatric healthcare: a review
Survival rates for children and adolescents diagnosed with malignancy have been steadily increasing due to advances in oncology treatments. These treatments can have a toxic effect on the gonads. Currently, oocyte and sperm cryopreservation are recognized as well-established and successful strategie...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189781/ https://www.ncbi.nlm.nih.gov/pubmed/37206440 http://dx.doi.org/10.3389/fendo.2023.1147898 |
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author | Chen, Lin Dong, Zirui Chen, Xiaoyan |
author_facet | Chen, Lin Dong, Zirui Chen, Xiaoyan |
author_sort | Chen, Lin |
collection | PubMed |
description | Survival rates for children and adolescents diagnosed with malignancy have been steadily increasing due to advances in oncology treatments. These treatments can have a toxic effect on the gonads. Currently, oocyte and sperm cryopreservation are recognized as well-established and successful strategies for fertility preservation for pubertal patients, while the use of gonadotropin-releasing hormone agonists for ovarian protection is controversial. For prepubertal girls, ovarian tissue cryopreservation is the sole option. However, the endocrinological and reproductive outcomes after ovarian tissue transplantation are highly heterogeneous. On the other hand, immature testicular tissue cryopreservation remains the only alternative for prepubertal boys, yet it is still experimental. Although there are several published guidelines for navigating fertility preservation for pediatric and adolescent patients as well as transgender populations, it is still restricted in clinical practice. This review aims to discuss the indications and clinical outcomes of fertility preservation. We also discuss the probably effective and efficient workflow to facilitate fertility preservation. |
format | Online Article Text |
id | pubmed-10189781 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101897812023-05-18 Fertility preservation in pediatric healthcare: a review Chen, Lin Dong, Zirui Chen, Xiaoyan Front Endocrinol (Lausanne) Endocrinology Survival rates for children and adolescents diagnosed with malignancy have been steadily increasing due to advances in oncology treatments. These treatments can have a toxic effect on the gonads. Currently, oocyte and sperm cryopreservation are recognized as well-established and successful strategies for fertility preservation for pubertal patients, while the use of gonadotropin-releasing hormone agonists for ovarian protection is controversial. For prepubertal girls, ovarian tissue cryopreservation is the sole option. However, the endocrinological and reproductive outcomes after ovarian tissue transplantation are highly heterogeneous. On the other hand, immature testicular tissue cryopreservation remains the only alternative for prepubertal boys, yet it is still experimental. Although there are several published guidelines for navigating fertility preservation for pediatric and adolescent patients as well as transgender populations, it is still restricted in clinical practice. This review aims to discuss the indications and clinical outcomes of fertility preservation. We also discuss the probably effective and efficient workflow to facilitate fertility preservation. Frontiers Media S.A. 2023-05-03 /pmc/articles/PMC10189781/ /pubmed/37206440 http://dx.doi.org/10.3389/fendo.2023.1147898 Text en Copyright © 2023 Chen, Dong and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Chen, Lin Dong, Zirui Chen, Xiaoyan Fertility preservation in pediatric healthcare: a review |
title | Fertility preservation in pediatric healthcare: a review |
title_full | Fertility preservation in pediatric healthcare: a review |
title_fullStr | Fertility preservation in pediatric healthcare: a review |
title_full_unstemmed | Fertility preservation in pediatric healthcare: a review |
title_short | Fertility preservation in pediatric healthcare: a review |
title_sort | fertility preservation in pediatric healthcare: a review |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189781/ https://www.ncbi.nlm.nih.gov/pubmed/37206440 http://dx.doi.org/10.3389/fendo.2023.1147898 |
work_keys_str_mv | AT chenlin fertilitypreservationinpediatrichealthcareareview AT dongzirui fertilitypreservationinpediatrichealthcareareview AT chenxiaoyan fertilitypreservationinpediatrichealthcareareview |