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Fertility preservation in pediatric healthcare: a review

Survival rates for children and adolescents diagnosed with malignancy have been steadily increasing due to advances in oncology treatments. These treatments can have a toxic effect on the gonads. Currently, oocyte and sperm cryopreservation are recognized as well-established and successful strategie...

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Detalles Bibliográficos
Autores principales: Chen, Lin, Dong, Zirui, Chen, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189781/
https://www.ncbi.nlm.nih.gov/pubmed/37206440
http://dx.doi.org/10.3389/fendo.2023.1147898
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author Chen, Lin
Dong, Zirui
Chen, Xiaoyan
author_facet Chen, Lin
Dong, Zirui
Chen, Xiaoyan
author_sort Chen, Lin
collection PubMed
description Survival rates for children and adolescents diagnosed with malignancy have been steadily increasing due to advances in oncology treatments. These treatments can have a toxic effect on the gonads. Currently, oocyte and sperm cryopreservation are recognized as well-established and successful strategies for fertility preservation for pubertal patients, while the use of gonadotropin-releasing hormone agonists for ovarian protection is controversial. For prepubertal girls, ovarian tissue cryopreservation is the sole option. However, the endocrinological and reproductive outcomes after ovarian tissue transplantation are highly heterogeneous. On the other hand, immature testicular tissue cryopreservation remains the only alternative for prepubertal boys, yet it is still experimental. Although there are several published guidelines for navigating fertility preservation for pediatric and adolescent patients as well as transgender populations, it is still restricted in clinical practice. This review aims to discuss the indications and clinical outcomes of fertility preservation. We also discuss the probably effective and efficient workflow to facilitate fertility preservation.
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spelling pubmed-101897812023-05-18 Fertility preservation in pediatric healthcare: a review Chen, Lin Dong, Zirui Chen, Xiaoyan Front Endocrinol (Lausanne) Endocrinology Survival rates for children and adolescents diagnosed with malignancy have been steadily increasing due to advances in oncology treatments. These treatments can have a toxic effect on the gonads. Currently, oocyte and sperm cryopreservation are recognized as well-established and successful strategies for fertility preservation for pubertal patients, while the use of gonadotropin-releasing hormone agonists for ovarian protection is controversial. For prepubertal girls, ovarian tissue cryopreservation is the sole option. However, the endocrinological and reproductive outcomes after ovarian tissue transplantation are highly heterogeneous. On the other hand, immature testicular tissue cryopreservation remains the only alternative for prepubertal boys, yet it is still experimental. Although there are several published guidelines for navigating fertility preservation for pediatric and adolescent patients as well as transgender populations, it is still restricted in clinical practice. This review aims to discuss the indications and clinical outcomes of fertility preservation. We also discuss the probably effective and efficient workflow to facilitate fertility preservation. Frontiers Media S.A. 2023-05-03 /pmc/articles/PMC10189781/ /pubmed/37206440 http://dx.doi.org/10.3389/fendo.2023.1147898 Text en Copyright © 2023 Chen, Dong and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chen, Lin
Dong, Zirui
Chen, Xiaoyan
Fertility preservation in pediatric healthcare: a review
title Fertility preservation in pediatric healthcare: a review
title_full Fertility preservation in pediatric healthcare: a review
title_fullStr Fertility preservation in pediatric healthcare: a review
title_full_unstemmed Fertility preservation in pediatric healthcare: a review
title_short Fertility preservation in pediatric healthcare: a review
title_sort fertility preservation in pediatric healthcare: a review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189781/
https://www.ncbi.nlm.nih.gov/pubmed/37206440
http://dx.doi.org/10.3389/fendo.2023.1147898
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