Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape

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Current capabilities in genomic sequencing outpace functional interpretations. Our previous work showed that 3D protein structure calculations enhance mechanistic understanding of genetic variation in sequenced tumors and patients with rare diseases. The KRAS GTPase is among the critical genetic fac...

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Detalles Bibliográficos
Autores principales: Ratnasinghe, Brian D., Haque, Neshatul, Wagenknecht, Jessica B., Jensen, Davin R., Esparza, Guadalupe V., Leverence, Elise N., De Assuncao, Thiago Milech, Mathison, Angela J., Lomberk, Gwen, Smith, Brian C., Volkman, Brian F., Urrutia, Raul, Zimmermann, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189839/
https://www.ncbi.nlm.nih.gov/pubmed/37207265
http://dx.doi.org/10.1101/2023.04.28.536249
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