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Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer
Tumor-infiltrating lymphocytes (TILs) are important components of the tumor microenvironment (TME). However, the distribution characteristics of TILs and their significance in pancreatic cancer (PC) remain largely unexplored. The levels of TILs, including the total number of T cells, cluster of diff...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189847/ https://www.ncbi.nlm.nih.gov/pubmed/37205920 http://dx.doi.org/10.3892/ol.2023.13847 |
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author | Sun, Gen Yang, Zhengjiang Fang, Kang Xiong, Yuanpeng Tu, Shuju Yi, Siqing Xiao, Weidong |
author_facet | Sun, Gen Yang, Zhengjiang Fang, Kang Xiong, Yuanpeng Tu, Shuju Yi, Siqing Xiao, Weidong |
author_sort | Sun, Gen |
collection | PubMed |
description | Tumor-infiltrating lymphocytes (TILs) are important components of the tumor microenvironment (TME). However, the distribution characteristics of TILs and their significance in pancreatic cancer (PC) remain largely unexplored. The levels of TILs, including the total number of T cells, cluster of differentiation (CD)4(+) T cells, CD8(+) cytotoxic T lymphocytes (CTLs), regulatory T-cells (Tregs), programmed cell death protein 1(+) T cells and programmed cell death ligand 1 (PD-L1)(+) T cells, in the TME of patients with PC were detected using multiple fluorescence immunohistochemistry. The associations between the number of TILs and the clinicopathological characteristics were investigated using χ(2) tests. In addition, Kaplan-Meier survival and Cox regression analyses were used to assess the prognostic value of these TIL types. Compared with paracancerous tissues, in PC tissues, the proportions of total T cells, CD4(+) T cells and CD8(+) CTLs were markedly decreased, while those of Tregs and PD-L1(+) T cells were significantly increased. The levels of CD4(+) T cell and CD8(+) CTL infiltrates were inversely associated with tumor differentiation. Higher infiltrates of Tregs and PD-L1(+) T cells were closely associated with advanced N and TNM stages. It is important to note that the infiltrates of total T cells, CD4(+) T cells, Tregs and PD-L1(+) T cells in the TME were independent risk factors for the prognosis of PC. PC was characterized by an immunosuppressive TME with a decrease in the number of CD4(+) T cells and CD8(+) CTLs, and an increase in the number of Tregs and PD-L1(+) T cells. Overall, the number of total T cells, CD4(+) T cells, Tregs and PD-L1(+) T cells in the TME was a potential predictive marker for the prognosis of PC. |
format | Online Article Text |
id | pubmed-10189847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-101898472023-05-18 Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer Sun, Gen Yang, Zhengjiang Fang, Kang Xiong, Yuanpeng Tu, Shuju Yi, Siqing Xiao, Weidong Oncol Lett Articles Tumor-infiltrating lymphocytes (TILs) are important components of the tumor microenvironment (TME). However, the distribution characteristics of TILs and their significance in pancreatic cancer (PC) remain largely unexplored. The levels of TILs, including the total number of T cells, cluster of differentiation (CD)4(+) T cells, CD8(+) cytotoxic T lymphocytes (CTLs), regulatory T-cells (Tregs), programmed cell death protein 1(+) T cells and programmed cell death ligand 1 (PD-L1)(+) T cells, in the TME of patients with PC were detected using multiple fluorescence immunohistochemistry. The associations between the number of TILs and the clinicopathological characteristics were investigated using χ(2) tests. In addition, Kaplan-Meier survival and Cox regression analyses were used to assess the prognostic value of these TIL types. Compared with paracancerous tissues, in PC tissues, the proportions of total T cells, CD4(+) T cells and CD8(+) CTLs were markedly decreased, while those of Tregs and PD-L1(+) T cells were significantly increased. The levels of CD4(+) T cell and CD8(+) CTL infiltrates were inversely associated with tumor differentiation. Higher infiltrates of Tregs and PD-L1(+) T cells were closely associated with advanced N and TNM stages. It is important to note that the infiltrates of total T cells, CD4(+) T cells, Tregs and PD-L1(+) T cells in the TME were independent risk factors for the prognosis of PC. PC was characterized by an immunosuppressive TME with a decrease in the number of CD4(+) T cells and CD8(+) CTLs, and an increase in the number of Tregs and PD-L1(+) T cells. Overall, the number of total T cells, CD4(+) T cells, Tregs and PD-L1(+) T cells in the TME was a potential predictive marker for the prognosis of PC. D.A. Spandidos 2023-05-02 /pmc/articles/PMC10189847/ /pubmed/37205920 http://dx.doi.org/10.3892/ol.2023.13847 Text en Copyright: © Sun et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Sun, Gen Yang, Zhengjiang Fang, Kang Xiong, Yuanpeng Tu, Shuju Yi, Siqing Xiao, Weidong Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer |
title | Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer |
title_full | Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer |
title_fullStr | Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer |
title_full_unstemmed | Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer |
title_short | Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer |
title_sort | distribution characteristics and clinical significance of infiltrating t cells in the tumor microenvironment of pancreatic cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10189847/ https://www.ncbi.nlm.nih.gov/pubmed/37205920 http://dx.doi.org/10.3892/ol.2023.13847 |
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